International Ceftriaxone Sodium Hydrate Injection 2 grams

Adult administration

Adults and children over 12 years old should receive 1–2g (potency) of ceftriaxone via intravenous or intramuscular injection once a day. In cases of severe disease or infections caused by moderately sensitive pathogens, the dose may be increased up to 4g (potency) once daily. Elderly patients may follow the same dosing as adults without any necessary modification. For gonorrhea treatment, a single intramuscular injection of 250mg (potency) is recommended.

Child administration

In infants (within 14 days of birth), administer 20–50mg/kg (potency) once daily, not exceeding 50mg (potency). In children and infants (15 days to 12 years old), administer 20–80mg/kg (potency) once daily.

This medication should not be used with calcium-containing solutions as it can cause dangerous precipitation. It should particularly not be administered to infants younger than 28 days when used with calcium solutions, as serious side effects can occur. Patients with a history of allergy to this medication or those with hypersensitivity to cephalosporins or penicillin antibiotics should not use it. Use is also contraindicated in premature infants or newborns with jaundice, hypoproteinemia, or acidosis. Special caution should be taken in patients with poor kidney function or a history of drug allergies, and dose adjustments may be required if necessary. Regular monitoring of liver function, kidney function, and blood tests is required during administration, and any abnormal symptoms should be reported to medical personnel immediately. Rarely, serious allergic reactions, skin rashes, blood abnormalities, or neurological issues may occur, so symptoms should be closely monitored. Women who are pregnant or breastfeeding should consult their doctor regarding the use of this medication, and it is safest to avoid use in newborns or premature infants. This medication may interact with other drugs, so if there are any other medications being taken, it is essential to inform medical personnel, with particular caution when used with calcium agents, diuretics, or aminoglycoside antibiotics. During administration, emergency equipment should be prepared, and the patient's condition should be closely observed, as symptoms such as dizziness can occur during driving or operating machinery. The prepared solution should be used as soon as possible, and when stored, the specified time and temperature should be observed.

Serious side effects

• Hives
• severe swelling (edema)
• shock
• anaphylaxis
• anaphylactoid reactions
• severe allergic reactions
• severe skin reactions
• erythema multiforme
• Stevens-Johnson syndrome
• toxic epidermal necrolysis

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• dizziness
• bronchospasm
• loose stools
• nausea

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture, preferably at a temperature between 1 to 30 degrees Celsius at room temperature. This storage method helps maintain the efficacy of the medication and prevent deterioration.

Appearance

A vial filled with a white to pale yellow crystalline powder

Package unit

10 vials/box [1 vial x 10]