Dongkwang Vancomycin Injection 1g (Vancomycin Hydrochloride)

Adult dosage

Adults: As Vancomycin, administer 500mg (potency) every 6 hours or 1g (potency) every 12 hours by slow intravenous infusion. For oral administration, adults generally take 500–2000mg divided into 3–4 doses for 7–10 days. The total daily dose should not exceed 2g.

Children's dosage

Pediatrics: Administer 10mg (potency) per kg of body weight by intravenous injection every 6 hours. Infants: Administer 10 to 15mg (potency) per kg of body weight by intravenous injection every 12 hours. For infants and newborns, administer 10mg of body weight.

This drug should not be used in patients with a history of shock caused by this drug. Additionally, patients who have shown allergic reactions to this drug or peptide antibiotics, aminoglycoside antibiotics should also avoid administration. Patients with hearing impairment or previous auditory damage due to peptide or aminoglycoside antibiotics should generally not use this drug, but it may be used cautiously when absolutely necessary. Patients with impaired kidney function should be cautious in administering this drug as it may accumulate in the body, and blood concentrations should be regularly monitored. Patients with poor liver function also require caution as liver function may worsen. Elderly patients, premature infants, newborns, and patients with damage to the vestibular organs and cochlea should also be particularly careful when using this drug. This drug can rarely cause severe allergic reactions such as shock or anaphylaxis to the central nervous system, so the patient's condition should be closely monitored during administration. Gastrointestinal side effects can include loose stools, diarrhea, nausea, vomiting, and abdominal pain. Hematological side effects may include decreased red blood cells, white blood cells, and platelets or increased eosinophils, and in some cases, serious blood disorders may occur. CNS side effects may include dizziness, tinnitus, and hearing loss, so regular hearing tests are recommended. Liver function tests may show elevated levels of bilirubin and various enzymes, so regular testing is necessary. Kidney function may decline, so blood BUN and creatinine levels should be periodically checked, and if abnormalities occur, the administration should be stopped or the dose adjusted. Severe skin reactions such as exfoliative dermatitis, vesicular dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis may occur, so skin condition should be diligently monitored. Adverse reactions may include rash, erythema, facial flushing, low blood pressure, wheezing, dyspnea, urticaria, and itching; symptoms like Red Man syndrome may occur with rapid infusion. Fever, vascular pain, phlebitis, nausea, chills may occur, and in rare cases, pseudomembranous colitis may occur, so if diarrhea or abdominal pain persists, the physician should be notified immediately. It is important to administer this drug for only the appropriate duration based on susceptibility testing to prevent the emergence of resistant bacteria. Patients with decreased kidney function or those using aminoglycoside antibiotics together with this drug have a higher risk of nephrotoxicity, so renal function must be continuously monitored. Long-term use can cause non-susceptible bacteria to proliferate excessively, so if abnormal symptoms appear, administration should be discontinued. Regular hearing tests are recommended to prevent auditory toxicity. Regular blood tests, liver function, and kidney function tests should be performed, and white blood cell counts should be closely monitored during long-term administration. The safety of this drug during pregnancy has not been fully established, so pregnant women or women of childbearing potential should only use it when the benefits outweigh the risks, and blood levels should be closely monitored to reduce fetal toxicity risk. Lactating women should avoid administration of this drug as it is secreted in breast milk or discontinue breastfeeding if it is absolutely necessary. Pediatric patients, especially premature infants and newborns, may have immature kidney functions, so careful dosage is required as blood levels may increase. Elderly patients may also commonly have decreased kidney function, so renal function tests should be conducted before and during administration, and doses adjusted as necessary. In cases of overdose, acute renal failure and hearing damage may occur, requiring appropriate supportive therapy and blood filtration treatment. This drug may cause tissue damage when injected intramuscularly, so it should be administered only by intravenous injection, and rapid infusion at high concentrations may lead to thrombotic phlebitis or hypotension, so it is necessary to dilute and administer slowly. This drug can cause chemical instability when mixed with other medications, so it is recommended to administer it through a separate intravenous line. Before administration of this drug, the solution should be visually checked for discoloration or particles.

Serious side effects

Shock, anaphylaxis symptoms, exfoliative dermatitis, vesicular dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, rash, erythema, facial flushing, hypotension, wheezing, respiratory distress, urticaria, itching, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), severe skin adverse reactions (SCAR), drug-induced hypersensitivity syndrome (DIHS), Red Man syndrome

Mild side effects

• Loose stools
• diarrhea
• nausea
• vomiting
• abdominal pain
• decreased red blood cells
• decreased white blood cells
• decreased platelets
• increased eosinophils
• dizziness

This drug should be stored in a sealed container to avoid contact with air, preferably at room temperature between 1 degree and 30 degrees Celsius. Storing it this way can maintain the drug's effectiveness and prevent deterioration.

Appearance

A colorless transparent vial containing light yellow-brown powder for injection

Package unit

10 vials