Unisimva Tablet 5 mg (Simvastatin)

Adult dose

For the treatment of hyperlipidemia, it is recommended to initiate treatment with a dose of 20 mg once daily in the evening. Patients with mild to moderate hypercholesterolemia can start with 10 mg. The recommended dosing is 5 to 40 mg taken once daily in the evening, and the dose may be adjusted according to baseline LDL-cholesterol level, treatment goals, and patient response before initiating treatment. Dose adjustments should be made by regularly measuring cholesterol levels at 4-week intervals or thereafter. If cholesterol levels are below the target, reduce the dose. Due to the increased risk of muscle damage including rhabdomyolysis, the use of 80 mg of this drug should be reserved only for patients who have been taking this dose for more than 12 months without evidence of muscle toxicity (refer to Warning under precautions).

Child dose

The recommended initial dose for pediatric patients (ages 10 to 17) with heterozygous familial hypercholesterolemia is 10 mg once daily in the evening. The recommended dosage range is 10 to 40 mg daily, with a recommended maximum dose of 40 mg per day.

This drug may have side effects affecting the muscles, so if muscle pain or weakness occurs, especially when taking high doses, consult a doctor immediately. This drug may affect liver function, so it should be avoided in patients with liver disease or elevated liver enzyme levels, and periodic liver function tests are important. Women who are pregnant or may become pregnant, as well as breastfeeding women, should not take this drug, and those planning to become pregnant should consult a doctor. When used in combination with certain medications, there may be an increased risk of muscle damage, so patients taking other drugs should inform their healthcare provider. Elderly patients, those with impaired kidney function, and patients with hypothyroidism need to use this drug with caution and should follow their doctor's instructions. This drug contains lactose, so patients with lactose intolerance should not take it. If unexplained muscle pain, tenderness, or weakness occurs while taking this drug, stop taking it immediately and consult a healthcare provider. Some patients may experience side effects such as dyspepsia, headache, constipation, diarrhea, so if symptoms are severe, consult a doctor. Avoid taking grapefruit juice or certain drugs while on this medication, as this may increase the drug's blood concentration and the risk of side effects. This drug can raise blood sugar levels, so patients at risk for diabetes should periodically check their blood sugar. When receiving prescriptions for new medications during treatment, inform your healthcare provider about this drug you are taking. This drug is not for use in children or patients under 10 years of age; pediatric patients should follow a doctor's instructions for use. Store this medication out of reach of children and keep it in its original container.

Serious side effects

Myopathy/rhabdomyolysis, severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor), severe skin adverse reactions (severe rash with fever, blisters, peeling skin, pain in mucous membranes of the mouth/eyes), respiratory problems (shortness of breath or difficulty breathing, asthma attacks, cough with fever and respiratory abnormalities, difficulty breathing), liver abnormalities (jaundice, yellowing of the skin or eyes, systemic symptoms,

Mild side effects

Abdominal pain, weakness, constipation, diarrhea, dyspepsia, bloating, nausea, headache, upper respiratory tract infection, atrial fibrillation, gastritis, insomnia, dizziness, bronchitis, sinusitis, eczema, urinary tract infection, muscle pain, muscle cramps, joint pain, specific cranial nerve dysfunction (taste disturbance, ocular movement disorder, facial paralysis, etc.), tremors, sensory disturbances, peripheral neuropathy, peripheral nerve paralysis, mental disorders, anxiety, sleep disturbances (including insomnia and nightmares), depression, alopecia,

This drug may be sensitive to air and moisture, so it should be stored in a closed container. Additionally, it is best to store this medication at room temperature between 1°C and 30°C. This will help maintain the medication's effect and ensure safe use.

Appearance

Light yellowish-brown round film-coated tablet

Package unit

30 tablets (10 tablets/PTP x 3)