Medication info
Clara Tablet 250mg (Clarithromycin)

Clara Tablet 250mg (Clarithromycin)

Prescription medicationTablet
Ingredient · strength
Clarithromycin›250mg / 1 tablet
Manufacturer / importer
Nexpharm Korea Co., Ltd.
Appearance
Yellow oval film-coated tablet
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Active

MFDS item code 201504186 · Approved 2015.06.29 · Insurance code 662503240

Summary

Main use
Treatment of respiratory, skin, and mycobacterial infections, and Helicobacter pylori infection associated with duodenal ulcers
Who uses it
Adults · Children
Adult dosage
Adults: Clarithromycin is usually administered at a dose of 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1~14), and administer omeprazole 40mg once daily for 28 days (days 1~28).
Children's dosage
Children 12 years of age or older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

Ingredients

Manufacturer
Nexpharm Korea Co., Ltd.

Efficacy & effects

Treatment of respiratory, skin, and mycobacterial infections, and Helicobacter pylori infection associated with duodenal ulcers

  • Bronchitis
  • pneumonia
  • pharyngitis
  • sinusitis
  • skin and soft tissue infections
  • mycobacterial infections
  • duodenal ulcer
View approved original text

This medication is an effective treatment for various bacteria, including common bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, as well as specific pathogens like Helicobacter pylori, Chlamydia, and Mycobacteria. It is particularly used for lower respiratory infections such as bronchitis and pneumonia, and upper respiratory infections such as pharyngitis and sinusitis. Additionally, it assists in the treatment of skin and soft tissue infections and is used for Mycobacterial infections. It also contributes to symptom improvement by eradicating Helicobacter pylori in patients with duodenal ulcers. This medication is used in the treatment of various infections, helping facilitate rapid recovery.

Dosage and Administration

Adult dosage

Adults: Clarithromycin is usually administered at a dose of 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1~14), and administer omeprazole 40mg once daily for 28 days (days 1~28).

Children's dosage

Children 12 years of age or older: Same as adults For children under 12 years of age, use clarithromycin dry syrup.

Precautions

This medication should not be used in patients who are allergic to specific ingredients. Patients with a history of hypersensitivity to clarithromycin or similar class antibiotics should also not be administered this medication. Patients with a history of cardiac arrhythmias or prolonged QT intervals should avoid this medication. Patients with severe liver impairment or significantly reduced kidney function should not take this medication. It is safer not to use this medication in pregnant or nursing women. Serious side effects may occur if this medication is taken with certain other drugs, so it is essential to inform the physician of any medications being taken. Liver and kidney functions should be monitored regularly while using this medication, and adverse reactions should be observed. If allergic reactions or severe adverse symptoms occur, the medication should be discontinued immediately and consult a healthcare professional. Caution is required as hearing loss or tinnitus may occur with prolonged or high-dose use. Children and elderly individuals may be more sensitive to the side effects of this medication and should be used with special care. If diarrhea or abdominal pain worsens during treatment, it should be reported immediately to a healthcare professional as serious gastrointestinal diseases such as colitis could arise. As with other antibiotics, resistance may develop, so it's crucial to take this medication for the exact duration prescribed by the physician. Patients with heart disease or liver or kidney disease should consult their healthcare professional before taking this medication, as dose adjustments may be necessary. Caution may be required when driving or operating machinery while taking this medication; avoid activities if dizziness or confusion is experienced after taking it. Overdose may lead to gastrointestinal disturbances or central nervous system abnormalities; therefore, the prescribed dosage and administration should be strictly followed.

Side effects

  • Shock
  • anaphylactic symptoms
  • respiratory distress
  • convulsions
  • flushing
  • rash
  • itching
  • hives
  • skin erythema
  • angioedema
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  • arthralgia
  • drug rash
  • abdominal bloating
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • malaise
  • flatulence
  • diarrhea
  • oral mucosal erosion
  • upper abdominal pain
  • thirst
  • teeth discoloration
  • pancreatitis
  • increased amylase
  • dysgeusia
  • anorexia
  • constipation
  • stool discoloration
  • membranous colitis
  • hemorrhagic colitis
  • fever
  • cough
  • respiratory distress
  • abnormal chest X-ray
  • eosinophilia
  • eosinophilic lung infiltration
  • interstitial pneumonia
  • chronic bronchitis
  • acute maxillary sinusitis
  • eosinophilia
  • thrombocytopenia
  • pancytopenia
  • hemolytic anemia
  • leukopenia
  • agranulocytosis
  • dizziness
  • depression
  • taste loss
  • smell loss
  • anxiety
  • insomnia
  • nightmares
  • tinnitus
  • confusion
  • disorientation
  • hallucinations
  • psychosis
  • depersonalization
  • convulsions
  • tremors
  • numbness
  • behavioral changes
  • manic behavior
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • allergic purpura
  • drug rash
  • jaundice
  • hepatocellular hepatitis
  • cholestatic hepatitis
  • increased liver enzymes
  • liver function impairment
  • liver failure
  • fulminant hepatitis
  • elevated AST
  • elevated ALT
  • elevated γ-GTP
  • elevated LDH
  • elevated ALP
  • increased total bilirubin
  • elevated serum creatinine
  • elevated BUN
  • interstitial nephritis
  • injection site phlebitis
  • injection site pain
  • injection site inflammation
  • fever
  • weakness
  • chest pain
  • chills
  • fatigue
  • abnormal albumin-globulin ratio
  • elevated serum alkaline phosphatase
  • elevated serum lactate dehydrogenase
  • increased INR
  • prolonged prothrombin time
  • urine discoloration
  • esophagitis
  • gastroesophageal reflux disease
  • gastritis
  • rectal pain
  • belching
  • bloating
  • tongue discoloration
  • vesicular dermatitis
  • hyperhidrosis
  • papular rash
  • acne
  • Henoch-Schonlein purpura
  • cardiac arrest
  • atrial fibrillation
  • ectopic beats
  • palpitations
  • vasodilation
  • asthma
  • epistaxis
  • pulmonary embolism

Not everyone experiences these, and they can vary from person to person.

Storage

This medication is sensitive to light, so it should be stored in a place that does not receive direct sunlight. Additionally, it should be stored at room temperature between 1 degree and 30 degrees Celsius and in a tightly sealed container to prevent air from entering.

Appearance and packaging

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.