Medifenacin Tablet 10mg (Solifenacin Succinate)

Adult dose

The usual recommended dose for adults (including older adults) is 5mg once daily. If necessary, the dose may be increased to a maximum of 10mg once daily. This drug may be taken with or without food and should be swallowed whole with water. Dosage adjustment is required in the following patients. 1. Patients with renal impairment No dosage adjustment is necessary in patients with mild or moderate renal impairment (creatinine clearance>30ml/min). In patients with severe renal impairment (creatinine clearance≤30ml/min), administer with caution and do not exceed 5mg once daily. 2. Patients with hepatic impairment No dosage adjustment is necessary in patients with mild hepatic impairment. In patients with moderate hepatic impairment (Child-Pugh Class B), administer with caution and do not exceed 5mg once daily. 3. Patients receiving potent cytochrome P450 3A4(CYP3A4) inhibitors In patients receiving ketoconazole or another potent CYP3A4 inhibitor (e.g., ritonavir, nelfinavir, itraconazole), limit the maximum daily dose to 5mg.

This medication should not be used in patients with urinary retention, severe gastrointestinal disorders, myasthenia gravis, or narrow-angle glaucoma. Additionally, it should not be administered to those with a hypersensitivity to this drug or its ingredients, patients undergoing hemodialysis, patients with severe liver dysfunction, or moderate liver dysfunction patients taking strong CYP3A4 inhibitors. This drug should be used cautiously in patients at risk of urinary retention or with gastrointestinal obstructive disease or reduced gastrointestinal motility. Patients with severe renal impairment or moderate liver impairment should have a maximum daily dose limited, and caution is warranted in those taking strong CYP3A4 inhibitors concurrently. This medication may cause side effects such as dry mouth, constipation, blurred vision, urinary retention, and dry eyes; therefore, if any abnormal symptoms occur, consult a healthcare professional. In particular, if serious allergic reactions such as angioedema or anaphylaxis occur, immediately discontinue use and seek appropriate treatment. Caution should be taken due to the risk of accidents resulting from drowsiness or blurred vision while driving or operating machinery. This medication may enhance effects or worsen side effects when used with other anticholinergic drugs, so inform healthcare providers about any medications being taken. Safety during pregnancy or lactation has not been established, so consultation with a physician is necessary before use. It is advisable not to use in children as safety and efficacy have not been confirmed. In case of overdose, seek appropriate treatment immediately at a hospital, and special treatment may be required if severe symptoms occur. Patients with heart disease or at risk of QT prolongation should exercise special caution when using this medication.

• Dry mouth
• constipation
• blurred vision
• urinary retention
• dry eyes
• nausea
• indigestion
• upper abdominal pain
• vomiting
• urinary tract infection

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Bright pink round film-coated tablets

Package unit

100 tablets (10 tablets/Blister*10)