Clavivo Tablet 500mg (Clarithromycin)

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be used in certain patients. Patients who are allergic to any ingredient in this medication or have a history of allergy to similar classes of antibiotics should not take it. Also, patients taking certain heart-related medications, those with liver dysfunction, severe kidney impairment, pregnant or nursing women, patients with central nervous system infections, etc., should refrain from using this medication. Since this medication is excreted through the liver and kidneys, caution is necessary for patients with liver or kidney dysfunction, and dose adjustments may be required. During administration, allergic reactions or severe side effects may occur; hence, any abnormal symptoms should be reported to healthcare professionals immediately. This medication may cause various side effects including gastrointestinal disturbances, skin rashes, neurological symptoms, liver dysfunction, etc., so if any discomfort arises during the course of treatment, it should be reported to healthcare professionals. To prevent antibiotic resistance or worsening of infection, it should only be taken for the period directed by the doctor, and doses should not be stopped or altered arbitrarily. Due to many drug interactions, it is essential to inform healthcare professionals of any other medications being taken, especially caution is needed when combined with heart-related medications, anticoagulants, certain sedatives, and other antibiotics. It is safest not to use this medication during pregnancy or lactation; if unavoidable, breastfeeding should be discontinued. In the elderly, caution is required as reduced kidney function may lead to increased drug concentration. In cases of overdose, gastrointestinal disturbances or mental symptoms may occur, so it is crucial to adhere to the prescribed dosage; if an overdose is suspected, immediate hospital care is necessary. During the use of this medication, caution is needed while driving or operating machinery as dizziness or confusion may occur.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, flatulence, diarrhea, oral mucosa erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, appetite loss, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, ageusia, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, tinnitus, auditory disabilities, hypoglycemia, tinnitus, hearing impairment, vomiting, purpuric rash, acute generalized pustular psoriasis, soft tissue infection, candidiasis, gastroenteritis, infection, vaginitis, shingles, superficial soft tissue infection, erythema multiforme, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylaxis-like reaction, hypersensitivity, anaphylactic reaction, angioedema, appetite loss, decreased appetite, hypoglycemia, insomnia, anxiety, neuroexcitability, loudness perception, psychotic disorder, confusion state, depersonalization, depression, disorientation, hallucinations, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, dystonia, non-vestibular vertigo, drowsiness, tremors, convulsions, ageusia, abnormal olfaction, anosmia, vestibular vertigo, hearing loss, hearing impairment, cardiac arrest, atrial fibrillation, QT prolongation on ECG, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, thirst, belching, distension, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, urticaria, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, elevated blood creatinine, elevated blood urea, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fatigue, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This medication is sensitive to light, so it should be stored in special containers that do not allow light exposure. Moreover, it should be kept at room temperature between 15 to 30 degrees Celsius, avoiding extreme hot or cold.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets / bottle, 200 tablets / bottle