Selpireed Tablets (Glymepiride)

Adult dose

Administer orally once daily. This medication should be taken before breakfast or just before the first meal. The initial dose is 1 mg of glymepiride, and the dosage can be increased by 1 mg at intervals of 1 to 2 weeks. Generally, there is minimal additional benefit when doses higher than 4 mg are used, although it may be increased up to 6 mg or 8 mg if necessary. If taking 4 mg once daily fails, consider switching to insulin therapy.

This medication should not be used in patients with insulin-dependent diabetes mellitus or in patients with diabetic ketoacidosis or coma. Additionally, patients with allergies to this medication, its components, sulfonylureas, or sulfonamide drugs should not be administered this drug. The safety has not been established in patients with severe impairment of liver or kidney function, and it is recommended to switch to insulin treatment in these cases. This medication should also not be used in pregnant women or breastfeeding mothers. In patients with severe infections or pre/post-surgical conditions, insulin therapy is recommended, and patients with gastrointestinal disturbances such as diarrhea or vomiting may have unstable absorption of the drug, increasing the risk of hypoglycemia. Also, since this medication contains lactose, it should not be administered to patients with genetic disorders affecting lactose metabolism. During the first week of treatment, there is an increased risk of hypoglycemia, so careful monitoring of blood sugar is necessary. Careful management is particularly needed for elderly patients, those with poor nutritional status or irregular eating habits, those whose physical activity and carbohydrate intake do not align, those who have changed eating patterns, and those who consume alcohol. Patients with reduced kidney or liver function, those who have overdosed on other medications, and those with thyroid or adrenal dysfunction also have an increased risk of hypoglycemia, requiring caution. In case of hypoglycemic symptoms, contact a doctor or pharmacist immediately, and dosage adjustments or changes in administration method may be necessary. This medication can cause hypoglycemia due to its blood sugar-lowering effect, with symptoms such as headache, severe hunger, nausea, vomiting, fatigue, anxiety, confusion, drowsiness, and decreased consciousness. Severe hypoglycemia can lead to coma, so if symptoms occur, immediate intake of sugar or seeking medical assistance is essential. Additionally, temporary blurring of vision or gastrointestinal symptoms may occur at the start of treatment due to changes in blood sugar. Rarely, liver dysfunction, changes in blood cell counts, or allergic reactions may occur, and any abnormal symptoms should be discussed with healthcare professionals immediately. When taking this medication, regular meals, exercise, and weight management should be maintained, and it is essential to consume sugar promptly in case of hypoglycemia. Artificial sweeteners are not effective in controlling hypoglycemia, so sugar intake is necessary. It is important to inform healthcare professionals of any changes in treatment or lifestyle patterns, as stress situations can complicate blood sugar control, potentially leading to a switch to insulin treatment. This medication can interact with several drugs, so consulting with healthcare providers is crucial if taking other medications. Caution is especially needed when used with drugs that raise or lower blood sugar. Some medications, such as beta-blockers, may mask the symptoms of hypoglycemia. Pregnant or breastfeeding women should avoid using this medication as it may harm the fetus or newborn; it is safer to switch to insulin treatment if necessary. The safety and efficacy in children have not been sufficiently established, so it is recommended not to use it in children under 18 years of age. For the elderly, since kidney function may be impaired, they should be administered the drug cautiously with dosage adjustments. In the case of overdose, hypoglycemia can be very dangerous, necessitating immediate emergency treatment at a medical institution, which may include inducing vomiting, blocking drug absorption, or administering glucose injections. This medication should be stored out of reach of children and kept in its original container for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, hypotension, shock, anaphylaxis, angioedema, Stevens-Johnson syndrome, impaired liver function (cholestasis, jaundice), hepatitis, brain seizures, loss of consciousness and coma, stroke-like symptoms, thrombocytopenia, leukopenia, hemolytic anemia, erythropenia, agranulocytosis, pancytopenia, thrombocytopenic purpura.

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• decreased agility or activity

This medication should be kept in a tightly closed container to protect it from air and moisture. It is best to maintain storage temperatures between 1 and 30 degrees Celsius to preserve the medication's effectiveness.

Appearance

Green rectangular tablets

Package unit

30 tablets/bottle, 300 tablets/bottle