Canazol 150 mg (Fluconazole)

Adult dose

The route of administration should be determined according to the patient's clinical condition. Oral formulations are absorbed rapidly and almost completely; therefore, the doses of oral formulations (tablets, capsules, dry syrup) and injectable formulations are the same. ○ Adults 1. Vaginal candidiasis: Administer a single oral dose of 150 mg of fluconazole. 2. Systemic candidiasis, including candidemia, disseminated candidiasis, and other invasive Candida infections (peritoneum, endocardium, lungs, urinary tract, etc.): The usual dose of this medicine is 400 mg once on the first day, followed by 200 mg once daily from the next day. The dose may be increased to 400 mg once daily according to the patient's response. The duration of treatment is determined according to clinical response and medical judgment. 3. Cryptococcal meningitis and cryptococcosis at other sites: The usual dose of this medicine is 400 mg once on the first day, followed by 200-400 mg once daily from the next day. The duration of treatment is determined by clinical and mycological response, but treatment should generally be continued for at least 6 ~ 8 weeks. 4. To prevent recurrence of cryptococcal meningitis in patients with AIDS, administer 200 mg of this medicine once daily indefinitely after the patient has completed all initial treatment. 5. Prevention of fungal infections in immunocompromised patients at risk due to neutropenia caused by cytotoxic chemotherapy, radiation therapy, or bone marrow transplantation: Administer 50-400 mg of this medicine once daily according to the patient's risk of fungal infection. A dose of 400 mg once daily is recommended for patients at very high risk of systemic fungal infections, such as those expected to have severe or prolonged neutropenia, as in bone marrow transplantation. In these patients, administer 400 mg starting 5-6 days before the expected onset of neutropenia and continue 400 mg for 1 week after the neutrophil count has increased to 1,000 cells/mm3 or more. 6. For onychomycosis, administer 150 mg once weekly and continue treatment until the fingernails or toenails have regrown (until new, uninfected nails have grown). Fingernails generally take 3-6 months to regrow and toenails 6-12 months; growth rate may vary by age and individual. In some cases, fingernails or toenails may remain damaged after successful treatment with long-term administration. For dermatophyte infections of the skin, including athlete's foot (tinea pedis), tinea corporis, jock itch (tinea cruris), and cutaneous candidiasis: The usual dose is 50 mg once daily or 150 mg once weekly for 2-4 weeks. However, athlete's foot may require treatment for 6 weeks depending on the course of the disease. For tinea versicolor, administer 50 mg once daily for 2-4 weeks. ○ Older adults If renal function is normal, the usual adult dose is administered. In the presence of renal impairment (creatinine clearance 50 mL/min or less), the dose should be reduced or the dosing interval extended. ○ Patients with renal impairment This medicine is excreted mainly in the urine unchanged. No dose adjustment is necessary for a single dose. If multiple doses are required, administer the usual dose only on the first day of treatment and adjust the dose from the next day as follows. Creatinine clearance (mL/min) / Recommended dose > 50 / 100 % of the usual dose ≤50 (not on dialysis) / 50% of the usual dose Patients on hemodialysis / 100% of the usual dose after each hemodialysis session Patients on hemodialysis should receive 100% of the usual dose after each hemodialysis session. On days when dialysis is not performed, reduce the dose according to creatinine clearance.

This medication should not be used in specific patients. Firstly, individuals with allergies to this drug or similar medications should not take it. Women who are pregnant or may become pregnant, as well as those who are breastfeeding, should not take this medication. Additionally, this medication may be harmful to patients taking specific heart medications or other drugs, so it should not be taken together with these. This drug contains lactose, so individuals with lactose intolerance or related genetic disorders should avoid taking it. Caution is required when using this medication in certain cases. For example, patients with a history of drug allergies or impaired kidney or liver function should use it cautiously. Those with heart disease or at risk of arrhythmias should also exercise caution when taking this drug. This medication can interact with various drugs metabolized in the liver, so individuals taking other medications should consult a physician or pharmacist. Possible side effects while taking this medication include headache, abdominal pain, diarrhea, vomiting, liver function abnormalities, and skin rashes. In severe cases, rare but serious side effects such as blood disorders or cardiac arrhythmias may occur, so any unusual symptoms should prompt immediate consultation with a healthcare professional. This medication may affect liver and kidney function, so patients who take it for an extended period or have severe illnesses need regular blood tests and assessments of liver and kidney function. Particularly, patients with AIDS or cancer should be cautious as skin reactions may worsen. There are many interactions with other medications, so if other drugs are being taken, healthcare professionals must be informed, and concurrent use with some medications is prohibited. Additionally, this medication may affect contraceptive effectiveness, so women of childbearing age should use effective contraception during and for a period after treatment. It is advisable for pregnant women not to take this medication, especially in the early trimester due to potential harm to the fetus. Breastfeeding women should also avoid this medication as it can be excreted in breast milk. The safety for infants under six months of age is not certain, so it should only be used when absolutely necessary. During treatment, dizziness or seizures may occur while driving or operating machinery, so caution is advised. In cases of overdose, hallucinations or unusual behavior may occur, and appropriate treatment should be received immediately at a hospital. This medication is primarily excreted through urine, so adequate fluid intake and, if necessary, dialysis can be beneficial.

Agranulocytosis, Leukopenia, Neutropenia, Thrombocytopenia, Anaphylaxis, Angioedema, Hypertriglyceridemia, Hypercholesterolemia, Hypokalemia, Insomnia, Drowsiness, Headache, Seizure, Dizziness, Paresthesia, Dysgeusia, Tremor, Vertigo, Torsade de pointes, QT prolongation, Abdominal pain, Diarrhea, Nausea, Vomiting, Indigestion, Bloating, Dry mouth, Increased ALT, Increased AST, Increased serum alkaline phosphatase, Cholestasis, Jaundice, Increased bilirubin, Hepatotoxicity, Liver failure, Hepatocellular necrosis, Hepatitis, Hepatocellular damage, Rash, Itching, Urticaria, Increased sweating, Drug rash, Toxic epidermal necrolysis, Stevens-Johnson syndrome, Acute generalized exanthematous pustulosis, Exfoliative dermatitis, Facial edema, Hair loss, Drug reaction with eosinophilia and systemic symptoms, Myalgia, Fatigue, Lethargy, Asthenia, Fever, Adrenal insufficiency, Hallucination, Agitated behavior

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and it is advisable to keep it at room temperature between 1 to 30 degrees Celsius. By storing it this way, the effectiveness of the drug can be maintained for a longer period.

Appearance

Pink rectangular tablets

Package unit

30 tablets/bottle