Celebrex Capsule 200 Milligrams (Celecoxib)

Adult dose

The minimum recommended dose of this drug should be adjusted according to the patient, and it may be administered regardless of meals. ○ Adults: 1. Osteoarthritis (degenerative arthritis): Take 200 mg of celecoxib once daily, or take 100 mg twice daily. 2. Rheumatoid arthritis: Take 100 mg or 200 mg of celecoxib twice daily. 3. Ankylosing spondylitis (AS): Administer 200 mg of celecoxib once daily, or 100 mg twice daily. If no effect is observed after 6 weeks, the dose may be increased to 400 mg per day. If no effect is observed after 6 weeks of treatment at 400 mg per day, another treatment method should be considered. 4. Acute pain and primary dysmenorrhea: The initial recommended dose is 400 mg of celecoxib, with an additional 200 mg administered on the first day of treatment if needed. From the second day of treatment, the recommended dose, if needed, is 200 mg twice daily. ○ Patients with hepatic impairment: For patients with moderate hepatic impairment (Child-Pugh Class II), the dose should be reduced to approximately 50% of the recommended daily dose.

This medication should be used with caution in individuals who regularly consume more than three alcoholic drinks per day, as it increases the risk of gastrointestinal bleeding, and consultation with a doctor or pharmacist is essential. This medication may increase the risk of serious cardiovascular side effects such as thrombosis, myocardial infarction, and stroke. These risks may increase with longer duration and higher dosages, so the lowest effective dose for the shortest duration should be used. Gastrointestinal side effects may include upper and lower gastrointestinal perforation, ulcers, and bleeding, especially in elderly patients or those with a history of gastrointestinal diseases. If symptoms like epigastric pain, dyspepsia, black stools, or hematemesis occur, immediate medical attention is required. This medication should not be administered to patients with a history of certain allergies or severe liver or kidney impairment, active peptic ulcers, inflammatory bowel disease, heart failure, ischemic heart disease, etc. Patients with impaired liver or kidney function, asthma, hypertension, edema, those on diuretics or ACE inhibitors, and the elderly should use this medication cautiously and require regular monitoring of their condition. This medication may cause various adverse reactions, with common side effects including dyspepsia, diarrhea, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, insomnia, anxiety, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, flushing, cough, vomiting, abdominal pain, bloating, gastric ulcers, dental problems, duodenal ulcers, elevated liver enzymes, itching, rash, petechiae, angioedema, hair loss, blistering dermatitis, peripheral edema, facial swelling, influenza-like illness, damage, headaches, leg cramps. During the course of treatment, regular monitoring of blood pressure, liver function, kidney function, and blood tests is recommended to detect any abnormalities, and dosage adjustment or cessation should be done if necessary. This medication is metabolized by specific enzymes (CYP 2C9) in the liver, so caution is advised when taken with drugs that inhibit or induce these enzymes, as blood concentration changes may occur. Additionally, interactions might arise when taken with aspirin, anticoagulants, diuretics, antihypertensives, lithium, methotrexate, etc., so all medications being taken should be disclosed to healthcare providers. It is advisable that women who are pregnant or may become pregnant, and nursing mothers, refrain from using this medication as it may pose risks to the fetus or newborn. Safety and efficacy in children and adolescents have not been established, so it should not be used in these populations. Elderly patients have a higher likelihood of decreased kidney, liver, and heart function, which may increase the risk of side effects when taking this medication, necessitating special monitoring. Dizziness or drowsiness may occur after taking this medication; therefore, it is safest to avoid driving or operating machinery. Finally, this medication should be stored out of reach of children and should not be transferred to other containers to maintain quality and safety.

Gastrointestinal bleeding, cardiovascular thrombotic reactions, myocardial infarction, stroke, perforation of the upper and lower gastrointestinal tract, ulcer, hemorrhage, bronchitis, sinusitis, upper respiratory infection, urinary tract infection, pharyngitis, rhinitis, anemia, thrombocytopenia, hypersensitivity, insomnia, anxiety, confusional state, dizziness, muscle tension, drowsiness, blurred vision, tinnitus, palpitations, congestive heart failure, arrhythmia, tachycardia, hypertension, flushing, cough, vomiting, abdominal pain, diarrhea, indigestion, bloating, gastric ulcer, dental disease, duodenal ulcer, esophageal ulcer, intestinal perforation, pancreatitis, elevation of liver enzymes, itching, rash, urticaria, petechiae, angioedema, alopecia, bullous dermatitis, peripheral edema, facial edema, influenza-like illness, injury, taste disturbance, albuminuria, cystitis, hematuria, dysuria, frequent urination, kidney stones, incontinence, urinary tract infection, blurred vision, cataracts, conjunctivitis, eye pain, glaucoma, ocular hemorrhage, retinal artery or vein occlusion, increased serum creatinine, increased β2-microglobulin, increased NAG, positive urinary hematuria, positive urinary protein, renal dysfunction, acute kidney failure, interstitial nephritis, elevated serum sodium, elevated serum potassium, increased BUN, increased CPK, diabetes, hypercholesterolemia, hyperglycemia, hypokalemia, hyperkalemia, increased NPN, increased creatinine, increased alkaline phosphatase, weight gain, anorexia, increased LDH, hypoglycemia, hyponatremia, bursitis, arthralgia, arthropathy, skeletal abnormalities, myalgia, cervical dystonia, synovitis, tendinitis, myositis, leg cramps, fractures, tendon rupture, pain in various regions, muscle stiffness, decreased hematocrit, increased hemoglobin, petechiae, nosebleeds, thrombocytopenic purpura, agranulocytosis, aplastic anemia, pancytopenia, leukopenia, granulomatous inflammation, contact dermatitis, injection site reactions, skin nodules, headache, leg cramps, sensory loss, migraine, neuralgia, neuropathy, sensory abnormalities, cerebral infarction, aseptic meningitis, ataxia, suicidal thoughts, loss of smell, loss of taste, exacerbation of allergies, allergic reactions, weakness, chest pain, fluid retention, generalized edema, facial edema, fatigue, malaise, fever, facial flushing, influenza-like syndrome, pain, peripheral pain, sepsis, sudden death, anaphylactoid reactions, vasculitis, pulmonary embolism, interstitial pneumonia, hepatitis, liver failure, fulminant hepatitis, liver necrosis, cholestasis, cholestatic hepatitis, jaundice, photosensitivity reactions, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, drug rash, acute generalized exanthematous pustulosis, exfoliative dermatitis, acute kidney failure, hyponatremia, tubular interstitial nephritis, nephrotic syndrome, minimal change disease glomerulonephritis, menstrual disorders, breast pain, menopausal symptoms, fibrocystic disease of the breast, thoracic neoplasm, dysmenorrhea, menstrual disorders, vaginal bleeding, vaginitis, prostate disorders, ovarian cysts, hearing loss, ear abnormalities, otalgia, hearing impairment

This medication should be stored in a tightly sealed container to prevent air exposure, ideally at room temperature between 15 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness and prevent deterioration.

Appearance

A capsule filled with white to light yellow powder, with upper and lower parts being white.

Package unit

Domestic Use - 30 Capsules/Bottle, Domestic Use - 100 Capsules/Bottle, Export - 30 Capsules/Box [(10 Capsules x 3 PTP)], Export - 100 Capsules/Box [(10 Capsules x 10 PTP)]