Clarin Tablets 500 mg (Clarithromycin)

Adult dosage

Adults: The usual dosage of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and creatinine clearance of 30mL/min or less, the dosage should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this drug per dose twice daily. In this case, it must be administered concomitantly with other antimycobacterial drugs such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this drug 3 times daily for 14 days together with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1–14), and omeprazole 40mg once daily for 28 days (days 1–28).

Children's dosage

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This drug should not be administered to certain patients. For example, patients who are allergic to any of the ingredients in this medication or have had hypersensitivity reactions to antibiotics in the same class should not use it. Additionally, patients with certain heart conditions or severely impaired liver or kidney function, as well as pregnant or nursing women, should not take this medication. Patients taking specific medications should also exercise caution as serious side effects may occur when this drug is combined with others. This drug should be administered carefully in patients with impaired liver or kidney function, heart disease, elderly patients, or those taking other antibiotics. Patients with a history of allergies or sensitivity to the dyes contained in this drug should also be cautious. While taking this drug, serious allergic reactions, skin rashes, gastrointestinal disturbances, abnormal liver function, impaired kidney function, and central nervous system symptoms may occur; therefore, if any unusual symptoms appear, the medical staff should be notified immediately. This drug can disturb the balance of intestinal bacteria, leading to diarrhea or colitis; thus, if persistent diarrhea occurs, administration should be stopped, and proper treatment is necessary. Additionally, this drug can interact with various medications, so if taking other medicines, it is essential to inform the medical staff, especially when used in conjunction with heart-related medications, anticoagulants, hypoglycemic agents, or steroids. It is safest for pregnant or nursing women not to use this drug, and if it must be used, nursing should be discontinued. Children or elderly patients, as well as those with impaired kidney or liver function, may require dose adjustments, so they should follow medical guidance. In case of overdose, gastrointestinal disturbances or central nervous system symptoms may occur, and immediate appropriate treatment should be sought at a medical facility. This drug should be stored at room temperature, away from light, and not refrigerated.

Shock, anaphylactic symptoms, dyspnea, convulsions, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, fecal discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, ageusia, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremor, paresthesia, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular or cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, kidney failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized exanthematous pustulosis (AGEP), muscle cramps, musculoskeletal stiffness, myopathy, elevated serum creatinine, elevated blood urea, kidney failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, anorexia, decreased appetite, insomnia, anxiety, nervousness, noise sensitivity, psychotic disorder, confusional state, depersonalization, depression, disorientation, hallucination, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorder, non-vestibular dizziness, drowsiness, tremor, convulsions, ageusia, hyperosmia, anosmia, vestibular dizziness, hearing impairment, tinnitus, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, thirst, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, sweating, vesicular dermatitis, itching, urticaria, papular rash, acne, Henoch-Schonlein purpura, myalgia, rhabdomyolysis, myopathy, kidney failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, lethargy, fever, asthenia, chest pain, chills, fatigue

This medication is sensitive to light, so it should be stored in a tightly closed container that blocks light. It is also important to store the medicine at room temperature between 15°C and 30°C.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 200 tablets/bottle