Huresto 20 mg (Rosuvastatin Calcium)

Adult dose

For patients with primary hypercholesterolemia, mixed dyslipidemia, and dysbetalipoproteinemia, the initial dose is 5 mg once daily, at any time of the day regardless of meals. If more LDL-cholesterol reduction is needed, the maintenance dose can be adjusted, and most patients are managed at a dose of 10 mg once daily. The maintenance dose should be adjusted based on LDL-cholesterol levels and treatment goals at intervals of at least 4 weeks.

Child dose

In pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the dosage is 5 mg to 20 mg once daily. The dosage should be adjusted according to the individual patient's treatment goals and liver function at intervals of at least 4 weeks.

This drug should not be administered to certain patients. For example, it is contraindicated in individuals with allergies to the components of this drug, those with liver function issues, muscle diseases, and patients with severely impaired kidney function. Women who are pregnant or breastfeeding, as well as women of childbearing potential who are not using appropriate contraception, should not take this medication. It should only be administered to women of childbearing age after explaining the low likelihood of pregnancy and fetal risks. Patients at high risk for muscle diseases, such as those with moderate to severe kidney impairment, hypothyroidism, a family history of muscle diseases, or alcoholics, should avoid high doses of this medication. This medication contains lactose and should not be administered to patients with lactose intolerance or certain genetic metabolic disorders. While taking this drug, patients with a history of excessive alcohol intake or liver disease need regular liver function tests. Patients with hypercholesterolemia due to hypothyroidism or nephrotic syndrome should first treat the underlying disease. Myalgia, myopathy, and rarely severe muscle breakdown (rhabdomyolysis) may occur; therefore, if muscle pain or weakness occurs, the physician must be notified immediately, and if necessary, blood tests should be conducted to check for muscle damage. This drug may interact with other medications; caution is especially advised when used in conjunction with fibrates, certain antibiotics, antifungals, and immunosuppressants. The combination with specific drugs may increase the blood concentration of this drug, thereby increasing the risk of side effects. Pregnant or breastfeeding women should not use this medication, and women who could become pregnant must use appropriate contraception. In case of overdose, there is no specific antidote, so symptomatic treatment and monitoring of liver function and muscle enzymes are necessary. This drug does not significantly affect the ability to drive or operate machinery, but caution should be exercised as dizziness may occur. Finally, this drug may rarely cause serious skin reactions, liver dysfunction, kidney problems, and other severe side effects, so if any unusual symptoms occur, consult healthcare personnel immediately.

Serious side effects

Allergic reactions including urticaria and angioedema, severe swelling (edema), tightness in the chest, difficulty breathing, respiratory distress, jaundice, hepatitis, increased transaminases, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), rhabdomyolysis, immune-mediated necrotizing myopathy, thrombocytopenia, severe muscle weakness, ocular myasthenia, polyneuropathy, peripheral neuropathy, kidney failure, acute tubular necrosis

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• myalgia
• weakness
• hematuria

This medication should be stored in a tightly sealed container away from exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius to preserve the drug's effectiveness and safety.

Appearance

Pink round film-coated tablets

Package unit

PTP - 30 tablets/PTP [(15 tablets/PTP x 2)]