Samsung Famciclovir Tablet (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this medicine orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this medicine orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine orally twice daily. Discontinue treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since creatinine clearance of this medicine is reduced in patients with renal impairment, dose adjustment should be undertaken with caution. The dosage for these patients is as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following equations. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. Since 4 hours of hemodialysis reduces the plasma concentration of this medicine by approximately 75%, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is required in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, no clear recommended dose has been established.

This medication should not be used by patients who are allergic to this drug or its components, including the active ingredient, penciclovir. Patients with kidney function problems need to be cautious when using this drug. Symptoms such as headache or nausea may occur while taking this drug; however, they are usually mild or moderate and not severe. Blood-related side effects may rarely include a decrease in platelet count, and there may also be a possibility of decreased white blood cells and neutrophils. It can affect the central nervous system, leading to potential symptoms such as dizziness, drowsiness, confusion, and hallucinations, so care should be taken if these symptoms occur. Gastrointestinal side effects such as nausea, vomiting, abdominal pain, and diarrhea may commonly appear. Liver function tests may show abnormalities, and jaundice may rarely occur, so it is important to monitor liver health. Skin rashes or itching may commonly occur, and rarely symptoms such as hives or facial swelling may arise. In patients with compromised kidney function, acute renal failure may occur, necessitating dosage adjustments. This medication does not cure genital herpes, so it is important to avoid sexual contact during treatment and maintain safe sexual practices. If symptoms like dizziness or drowsiness occur, it is advisable to avoid driving or operating machinery. Generally, elderly patients may not need dosage adjustments; however, in cases of reduced kidney function, dosage should be modified. In the event of an overdose, it is important to contact a medical institution immediately for appropriate treatment, and the drug concentration can be decreased through hemodialysis. The drug should be stored in a tightly sealed container to prevent exposure to air or moisture. It is also advisable to keep it in a cool, dry place below 30 degrees Celsius. Care should be taken not to transfer the medication to other containers as this may affect its quality.

• Headache
• nausea
• thrombocytopenia
• leukopenia and neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations
• vomiting

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it should be stored in a cool, dry place below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

Domestic - 21 tablets/bottle