Famciclovir 250 mg Tablets

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of primary genital herpes infection Adults: Administer this medicine 250 mg orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer this medicine 125 mg orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer this medicine 250 mg orally twice daily. Temporarily discontinue treatment periodically every 6∼12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Because the clearance of this medicine is reduced in patients with renal impairment, adjust the dose with caution. The dosage for these patients is as follows. 1) Treatment of herpes zoster and primary genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg twice daily 10～29: 250 mg once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 125 mg twice daily 10～29: 125 mg once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) 30～59: 250 mg twice daily 10～29: 125 mg twice daily 4) If only serum creatinine is known, creatinine clearance may be calculated using the following formula: Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis In patients undergoing hemodialysis, it is preferable to administer this medicine every 48 hours, taking the dialysis interval into account. A 4-hour hemodialysis session reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication should not be administered to certain patients. Patients who are allergic to this medication or its ingredients should not take it. Also, since this medication contains lactose, patients with genetic issues related to lactose digestion should not take it. Patients with impaired kidney function should exercise caution when using this medication, and dose adjustment may be necessary. While taking this medication, symptoms such as headaches or nausea may occur, but they are usually mild. Additionally, a variety of side effects such as blood-related issues, neurological symptoms, digestive problems, and skin rashes may rarely occur, so if unusual symptoms appear, you should inform healthcare professionals immediately. This medication does not completely cure genital herpes, so if symptoms persist during treatment, it is advisable to avoid sexual contact. Maintaining safe sexual practices is also recommended. There is no evidence that this medication affects driving or operation of machinery, but caution should be taken in the case of dizziness or drowsiness. Patients with slightly impaired liver function do not typically require special dose adjustments, but those with severe liver dysfunction may experience reduced effectiveness of this medication. When taken in conjunction with other medications, the possibility of interactions exists, so consultation with healthcare professionals is required. Special caution is needed especially when taken with medications that affect renal clearance. Women who are pregnant or may become pregnant should consult a physician before taking this medication, and nursing mothers should also consult a professional before use. Children under 18 years of age should generally avoid this medication as its safety and efficacy have not been sufficiently established. Older patients usually do not require dose adjustments, but adjustments may be needed if kidney function is impaired. If an overdose occurs, immediate medical attention should be sought for appropriate treatment, and some of the medication can be removed through blood dialysis. This medication should be stored in a dry place below 30 degrees Celsius, and kept out of reach of children. Additionally, transferring to another container should be avoided as it may negatively affect quality.

• Headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is also advisable to store it in a cool, dry place below 30 degrees Celsius.

Appearance

White circular film-coated tablets

Package unit

21 tablets ((7 tablets/PTP)x3)