Medication info
Chromycin Tablet 500mg (Clarithromycin)

Chromycin Tablet 500mg (Clarithromycin)

Prescription medicationTabletOral
Ingredient · strength
Clarithromycin›500mg / 1 tablet
Manufacturer / importer
Hanwha Pharmaceutical Co., Ltd.
Appearance
Yellow rectangular film-coated tablet
Packaging
30 tablets/bottle, 100 tablets/bottle
Approval status
Active

MFDS item code 201404528 · Approved 2014.09.30 · Insurance code 651601760

Summary

Main use
Infections (respiratory, skin, mycobacterial, etc.); Helicobacter pylori eradication therapy
Who takes it
Adults · Children
Adult dose
○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: For 14 days, administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (1~14 days), and omeprazole 40mg once daily for 28 days (1~28 days).
Child dose
Children aged 12 years and older: same as adults For children under 12 years of age, use clarithromycin dry syrup.

Ingredients

Manufacturer
Hanwha Pharmaceutical Co., Ltd.

Efficacy & effects

Infections (respiratory, skin, mycobacterial, etc.); Helicobacter pylori eradication therapy

  • Bronchitis
  • pneumonia
  • pharyngitis
  • sinusitis
  • skin and soft tissue infections
  • mycobacterial infections
  • duodenal ulcers
View approved original text

This medication is effective in treating lower respiratory tract infections such as pneumonia and bronchitis, as well as upper respiratory tract infections like pharyngitis and sinusitis. It is also used for skin and soft tissue infections, and is helpful in infections caused by mycobacteria, particularly Mycobacterium avium and intracellular infections. In patients with duodenal ulcers, it is used to eradicate Helicobacter pylori. The active ingredient exhibits antibacterial effects against various bacteria, aiding in the alleviation of infection symptoms. Therefore, it can effectively treat various types of bacterial infections.

How to take

Adult dose

○ Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7~14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. ○ Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Eradication of Helicobacter pylori in patients with duodenal ulcers: For 14 days, administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (1~14 days), and omeprazole 40mg once daily for 28 days (1~28 days).

Child dose

Children aged 12 years and older: same as adults For children under 12 years of age, use clarithromycin dry syrup.

Precautions

This medication should not be administered to certain patients. First, patients who are allergic to any components of this medication or have had hypersensitivity reactions to similar antibiotics should not use it. Additionally, it is prohibited for patients with specific heart diseases, severely impaired liver and kidney function, and for pregnant or breastfeeding women. This medication may cause arrhythmias or serious side effects if taken with certain drugs, so any current medications should be disclosed to the doctor or pharmacist. Caution is required when administering this medication to patients with reduced liver or kidney function, elderly patients, or those with heart diseases, and dosage adjustments may be necessary. Various side effects such as allergic reactions, gastrointestinal disturbances, liver dysfunction, kidney dysfunction, skin rashes, central nervous system effects may occur; any abnormal symptoms should be reported to healthcare providers immediately. Furthermore, this medication can alter the intestinal microbiota, potentially leading to diarrhea or severe colitis. If diarrhea persists for an extended period or abdominal pain worsens, discontinuation and appropriate treatment should be sought immediately. Regular blood tests and checks on liver and kidney function are important during the use of this medication to monitor for anomalies. In case of overdose, gastrointestinal disturbances and neurological symptoms may arise, so it's crucial to adhere to the prescribed dosage and seek medical attention immediately in case of excessive intake. Lastly, this medication is not to be administered to patients with specific genetic metabolic disorders, and caution should be exercised while driving or operating machinery as dizziness or confusion may occur during use.

Side effects

  • Shock
  • anaphylactic symptoms
  • dyspnea
  • convulsion
  • erythema
  • rash
  • pruritus
  • urticaria
  • skin erythema
  • angioedema
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  • joint edema
  • drug rash
  • abdominal distension
  • nausea
  • vomiting
  • dyspepsia
  • abdominal pain
  • discomfort
  • bloating
  • diarrhea
  • oral erosion
  • upper abdominal pain
  • thirst
  • transient tooth discoloration
  • pancreatitis
  • increased amylase
  • altered taste
  • decreased appetite
  • constipation
  • discoloration of feces
  • colitis
  • hemorrhagic colitis
  • fever
  • cough
  • increased eosinophils
  • eosinophilic lung infiltration
  • interstitial pneumonia
  • chronic bronchitis
  • acute maxillary sinusitis exacerbation
  • increased eosinophils
  • thrombocytopenia
  • pancytopenia
  • hemolytic anemia
  • leukopenia
  • agranulocytosis
  • dizziness
  • depression
  • loss of taste
  • loss of smell
  • anxiety
  • insomnia
  • nightmares
  • tinnitus
  • confusion
  • disorientation
  • hallucination
  • psychosis
  • depersonalization
  • convulsion
  • tremor
  • numbness
  • Stevens-Johnson syndrome
  • toxic epidermal necrolysis
  • allergic purpura
  • drug rash (DRESS)
  • jaundice
  • hepatocellular hepatitis
  • cholestatic hepatitis
  • increased liver enzymes
  • liver dysfunction
  • liver failure
  • fulminant hepatitis
  • elevated AST
  • elevated ALT
  • elevated γ-GTP
  • elevated LDH
  • elevated ALP
  • increased total bilirubin
  • elevated serum creatinine
  • elevated BUN
  • interstitial nephritis
  • renal failure
  • rhabdomyolysis
  • inflammation of the tongue
  • stomatitis
  • oral candidiasis
  • QT prolongation
  • ventricular tachycardia
  • Torsades de pointes
  • malaise
  • headache
  • taste disturbance
  • hearing loss
  • paresthesia
  • arthralgia
  • myalgia
  • olfactory disturbance
  • tinnitus
  • hearing impairment
  • hypoglycemia
  • tinnitus
  • hearing loss
  • vomiting
  • purpuric rash
  • acute generalized pustular eruption
  • rash
  • hyperhidrosis
  • vesicular dermatitis
  • papulopustular rash
  • acne
  • Henoch-Schonlein purpura
  • muscle spasms
  • musculoskeletal rigidity
  • myopathy
  • elevated blood creatinine
  • elevated blood urea
  • nephritis
  • phlebitis at injection site
  • pain at injection site
  • inflammation at injection site
  • fever
  • weakness
  • chest pain
  • chills
  • fatigue
  • abnormal albumin-globulin ratio
  • elevated serum alkaline phosphatase
  • elevated serum lactate dehydrogenase
  • increased INR
  • prolonged prothrombin time
  • urine discoloration

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be stored in a sealed container to prevent exposure to air and moisture. It is advisable to keep it in a cool place with low humidity and shielded from light, specifically at temperatures between 15 degrees and 30 degrees Celsius.

Appearance and packaging

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.