Clarithromycin Tablets

Adult dose

Adults: The usual dose is 250mg (potency) of clarithromycin per dose, twice daily; for severe infections, administer 500mg (potency) per dose, twice daily. The usual duration of treatment is 7～14 days. For patients with renal failure whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose, twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults For children under 12 years, use clarithromycin dry syrup.

This drug should not be used in patients with an allergy to specific components. Patients who have previously shown hypersensitivity to antibiotics in the same class should also avoid administration. Patients taking certain heart-related medications with this drug may have an increased risk of heart rhythm abnormalities, thus they should not use this drug. Patients with a history of arrhythmia or heart disease should use this drug cautiously, and those with severely impaired liver or kidney function should also avoid or use it carefully. It is advisable for pregnant or breastfeeding women to avoid taking this drug. This drug may have various side effects, so if abnormal symptoms such as skin rash, difficulty breathing, severe dyspepsia, or auditory disturbances occur, medical consultation should be sought immediately. Although rare, severe skin reactions or liver dysfunction can occur, so treatment should be stopped and medical care sought immediately if symptoms arise. This drug may interact with other medications, hence informing healthcare professionals about any medications being taken is essential. Patients with impaired kidney or liver function may require dose adjustments, so they should follow healthcare provider instructions. Long-term or high-dose use may cause hearing impairment or tinnitus, so treatment should be discontinued if these symptoms occur. If diarrhea or abdominal pain persists during treatment, it may indicate a serious bowel condition like pseudomembranous colitis, thus immediate consultation with healthcare professionals is necessary. Older patients should use this drug with caution due to the potential for increased drug concentrations caused by reduced physical function. This drug can cause dizziness or confusion when driving or operating machinery, so caution is required. In the event of an overdose, gastrointestinal disturbances or central nervous system symptoms may occur; thus, the prescribed dosage must be strictly adhered to. Lastly, it is important to take this medication for the prescribed duration only, as instructed by the physician, to prevent the development of antibiotic resistance.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, convulsive form, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, taste disorder, anorexia, constipation, color change in stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, orientation disturbance, hallucinations, psychosis, depersonalization, convulsions, tremors, numbness, behavior change, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, hepatic dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, anorexia, jaundice, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased myoglobin in blood, increased myoglobin in urine, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, lethargy, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory dysfunction, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, increased amylase, elevated total bilirubin, increased SGPT, elevated BUN, thrombocytopenia, elevated AST, elevated ALT, leukopenia, thrombocytopenia, anorexia, hypoglycemia, insomnia, anxiety, nervousness, noise intolerance, psychotic disorder, confusion state, depersonalization, depression, orientation disturbance, hallucinations, abnormal dreams, mania, taste disorder, headache, loss of consciousness, movement disorder, non-vestibular dizziness, drowsiness, tremors, convulsions, loss of taste, abnormal olfaction, loss of smell, vestibular dizziness, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, electrocardiogram QT prolongation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, vomiting, dyspepsia, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, dry mouth, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, liver failure, hepatocellular jaundice, rash, sweating, vesicular dermatitis, itching, urticaria, papular rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash (DRESS), acne, Henoch-Schonlein purpura, acute generalized pustular dermatitis, muscle spasms, musculoskeletal rigidity, myalgia, rhabdomyolysis, myopathy, elevated creatinine in the blood, elevated urea in the blood, renal failure, nephritis, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, lethargy, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated alkaline phosphatase in the blood, elevated lactate dehydrogenase in the blood, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

Store this medication in a cool, dry place, avoiding direct sunlight, ideally at room temperature between 1°C and 30°C. It is important to keep it in a tightly sealed container to avoid air exposure.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle