Clarithromycin 250 mg tablet

Adult dose

Adults: The usual dose is 250mg (potency) of clarithromycin per dose, administered twice daily; for severe infections, 500mg (potency) per dose is administered twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose, twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) per dose three times daily for 14 days (1～14 days), and administer omeprazole 40mg once daily for 28 days (1～28 days).

Child dose

Children 12 years of age and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be administered to certain patients. It should not be used in case of hypersensitivity to its components or allergies to similar antibiotics. It should also not be given to patients with specific heart conditions, severe liver impairments, or significant kidney dysfunction, as well as to pregnant or breastfeeding women. There are medications that should not be taken concurrently with this medication, so it is essential to consult a doctor or pharmacist about any current medications being taken. Since this medication is primarily excreted through the liver and kidneys, caution is required in patients with liver or kidney issues. Elderly patients and those with heart conditions should also be careful when using this medication. During the course of treatment, allergic reactions, gastrointestinal disturbances, skin rashes, neurological symptoms, and others may occur; in such cases, medical personnel must be notified immediately. If severe allergic reactions or skin disorders arise, administration should be stopped, and emergency treatment should be sought. This medication may alter intestinal flora, potentially leading to gastrointestinal issues such as diarrhea or colitis, so if persistent diarrhea occurs, administration should be discontinued and a doctor consulted. Due to the possibility of drug interactions altering medication levels, current treatments must be disclosed to a doctor or pharmacist. Concurrent use with drugs that may affect the heart or liver metabolism should be avoided. It is safer to avoid using this medication during pregnancy or breastfeeding, and if unavoidable, breastfeeding should be discontinued. For children, safety has not been established for those under 12 years of age when using tablets, and some formulations are not recommended for infants under 6 months. Elderly patients may require dose adjustments due to reduced kidney function. Overdosing on this medication may cause gastrointestinal disturbances or psychiatric symptoms, so it is crucial to adhere to the prescribed dosage, and in case of overdose, immediate consultation with a healthcare facility should be sought. Finally, during the course of this medication, dizziness or confusion may occur while driving or operating machinery, so caution is advised.

Shock, anaphylactic symptoms, dyspnea, seizures, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, fecal discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, seizures, tremors, numbness, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash associated with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, dysgeusia, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorder, hearing impairment, cardiac arrest, atrial fibrillation, QT interval prolongation on ECG, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, acute pancreatitis, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papulopustular rash, acne, Henoch-Schonlein purpura, acute generalized pustular dermatitis, muscle cramps, musculoskeletal rigidity, myopathy, nephritis, phlebitis at the injection site, pain at the injection site, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine discoloration, changes in mental state, obsessive behavior, hypokalemia, hypoxemia

This medication should be stored in a light-protected container at room temperature, specifically between 1 and 30 degrees Celsius. It is also important to keep it in a tightly sealed container to prevent air exposure.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle