Clarithromycin Tablet 500mg (Clarithromycin)

Adult dose

○ Adults: The usual dose is 250mg (potency) of clarithromycin per dose, twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7~14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this drug to these patients for more than 14 days. ○ Mycobacterial infections: Administer 500mg (potency) of this drug per dose, twice daily. In this case, it should be administered concomitantly with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. ○ Helicobacter pylori eradication in patients with duodenal ulcer: Administer 500mg (potency) of this drug 3 times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1~14), and administer omeprazole 40mg once daily for 28 days (days 1~28).

Child dose

Children 12 years of age and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be used in certain patients. For example, it should not be administered to those with an allergy to any of the components of this drug or to antibiotics with a similar structure. In addition, it is safe not to use this medication for patients taking drugs that may affect heart rhythm, those with heart disease, or those with severe impairment of liver or kidney function. Pregnant or breastfeeding women should also avoid taking this medication, and it should not be given to patients with central nervous system infections. When administering this drug, careful observation and dosing adjustments are necessary for patients with mild liver or kidney impairment, elderly patients, patients with heart disease, and those taking other specific medications. This medication may cause various side effects, including allergic reactions, gastrointestinal disturbances, liver function abnormalities, kidney issues, skin reactions, and central nervous system abnormalities. If any unusual symptoms occur while taking it, immediate consultation with a physician is necessary. In particular, symptoms such as unusual heart rhythms or severe allergic reactions may occur, and if these symptoms appear, the medication should be discontinued immediately, and appropriate treatment should be sought. This medication has many drug interactions, so if other medications are taken, it is essential to inform healthcare providers, as dose adjustments or discontinuation may be required when used in conjunction with some drugs. Pregnant or lactating women should ideally avoid taking this medication, and if it needs to be taken, a thorough consultation with a specialist is necessary. Special care is needed when administering this medication to children or the elderly, and dose adjustments or monitoring may be required. To prevent the occurrence of antibiotic-resistant bacteria, it is important that this medication is used only for the necessary duration after a susceptibility test, as long-term or repeated use could lead to resistance. Additionally, if persistent diarrhea or abdominal pain occurs during treatment with this medication, it is crucial to consult healthcare providers, as serious gastrointestinal conditions such as pseudomembranous colitis may develop. In case of overdose, gastrointestinal disturbances or central nervous system abnormal symptoms may appear, so if overdose is suspected, immediate medical attention should be sought for appropriate treatment. Finally, this medication can affect driving or machine operation abilities, so caution is necessary when engaging in these activities while on this medication.

Shock, anaphylactic symptoms, difficulty breathing, convulsions, redness, rash, itching, hives, erythema, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral erosion, upper abdominal pain, thirst, transient teeth discoloration, pancreatitis, increased amylase, taste disturbance, decreased appetite, constipation, stool discoloration, pseudomembranous colitis, hemorrhagic colitis, fever, cough, eosinophilia, eosinophilic lung infiltrates, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, anosmia, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, hepatic dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, increased total bilirubin, decreased appetite, dark-colored urine, pruritus, abdominal tenderness, elevated serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, increased serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, taste disorder, auditory loss, dysesthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, auditory impairment, hypoglycemia, purpuric rash, acute generalized pustular eruption, muscle cramps, musculoskeletal rigidity, myopathy, elevated blood urea, nephritis, phlebitis at the injection site, injection site pain, injection site inflammation, fever, asthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased INR, prolonged prothrombin time, urine discoloration

This medication is sensitive to light, so it should be stored in a container that does not allow light to penetrate. Also, it is recommended to store the medication at room temperature between 15 to 30 degrees Celsius, away from excessively hot or cold environments.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle