Humethin Tablets (Cimetidine)

Adult dose

As cimetidine, 400 mg per dose, administered orally twice daily (morning, bedtime) or 800 mg once daily (at bedtime). Additionally, it can be administered as 300 mg per dose four times daily (after meals, at bedtime). The dose may be increased to 400 mg per dose four times a day (after meals, at bedtime) (total 1.6 g). In cases of acute gastritis or acute exacerbations of chronic gastritis, administer 200 mg per dose twice daily or 400 mg once daily.

Child dose

Administer 20 to 40 mg per kg of body weight daily, divided and given orally.

This medication contains cimetidine and should not be administered to certain patients. Firstly, it should not be used in patients who have had allergic reactions to this medication or cimetidine. Also, patients taking dofetilide are at increased risk of cardiac arrhythmia, so it is not administered. This medication contains lactose, so it should not be given to patients with lactose intolerance or certain genetic sugar absorption disorders. Patients with impaired renal or liver function, history of drug allergies, elderly patients, children under 19 years of age, and patients undergoing hemodialysis should use it cautiously. Especially in patients with renal impairment, drug concentration in the blood may increase, requiring dosage adjustment or alteration of the dosing interval. This medication may mask symptoms of gastric cancer, so it should only be administered after ruling out malignancy. Patients with gastric ulcers infected with Helicobacter pylori should receive treatment to eradicate the bacteria. This medication may have multiple side effects, and if fatigue, bleeding, or fever occurs due to a decrease in blood cell counts, the medication should be stopped immediately and blood tests performed. There is also a rare risk of liver dysfunction, jaundice, and symptoms of hepatitis, so caution is warranted. If symptoms of renal impairment or abnormalities in blood tests occur, the medication should be stopped immediately. Allergic reactions may present as shock, respiratory distress, or skin rashes, and if these symptoms occur, administration should be halted. Endocrine side effects such as gynecomastia, excessive milk secretion, and erectile dysfunction have also been reported. Gastrointestinal symptoms such as abdominal bloating, constipation, and diarrhea may occur. Neurological symptoms such as headache, dizziness, seizures, drowsiness, and confusion may manifest, so if any abnormal signs occur, consulting a physician immediately is advised. Abnormal heart rhythms or severe skin rashes, or skin exfoliation have been reported rarely as well, so caution is necessary. Patients may also experience fatigue, fever, urinary difficulties, muscle pain, and hair loss while taking this medication. Additionally, this medication can interact with many other medications, so particularly with anticoagulants, anxiolytics, and cardiac drugs, a consultation with a physician is essential. Women who are pregnant or may become pregnant should use this medication cautiously only when necessary, as its safety has not been established, and breastfeeding mothers should discontinue breastfeeding when taking this medication. In children or elderly patients, dosage adjustments and monitoring are required due to the increased risk of elevated drug concentration due to diminished renal function. In cases of overdose, serious symptoms such as respiratory depression may occur, and immediate emergency treatment is required. This medication should be stored out of reach of children and not transferred to other containers for safety. If there is no therapeutic effect or severe side effects, the medication should be discontinued and a physician consulted to consider alternative treatments.

Serious side effects

• General malaise, weakness, subcutaneous bleeding, mucosal bleeding, fever (initial symptom of blood system abnormalities)
• Jaundice
• Fever, renal function abnormalities (increased BUN, creatinine, etc.)
• Shock, anaphylactic-like reactions (generalized rash, respiratory distress, etc.)
• Altered consciousness, convulsions
• Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), epidermal necrosis, erythema multiforme, exfoliative dermatitis, general exfoliative erythema
• Respiratory depression accompanied by cyanosis of the lips.

Mild side effects

• Leukopenia
• granulocytopenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• immune hemolytic anemia
• hepatitis
• increased AST
• ALT

This medication should be stored in a closed container that blocks light and at a temperature between 1 to 30 degrees Celsius. This storage helps maintain effectiveness and prevent degradation.

Appearance

Light green to green round film-coated tablet

Package unit

30 tablets/bottle, 1000 tablets/bottle