Clarithromycin Tablet 250mg

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily; for severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7~14 days. In patients with renal failure and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days to these patients. Mycobacterial infections: Administer 500mg (potency) of this drug twice daily. In this case, it should be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, or rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer this drug 500mg (potency) three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1~14), and omeprazole 40mg once daily for 28 days (days 1~28).

Child dose

Children 12 years of age and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This medication should not be administered to patients with certain allergic reactions. Particularly, individuals who have had hypersensitivity to this drug's components or similar antibiotics should avoid using it. Patients with a history of cardiac arrhythmias or QT prolongation, severe liver impairment, or significantly reduced kidney function should not receive this medication. It is also advisable for pregnant or breastfeeding women to avoid this drug. This medication should be used with caution in patients with impaired liver or kidney function, heart disease, and the elderly. Caution is also required when used together with other antibiotics or some medications due to potential drug interactions. Notably, the risk of side effects may increase when used in combination with certain heart-related medications or statins. If symptoms such as allergic reactions, severe skin rashes, difficulty breathing, heart abnormalities, liver function issues, or decreased kidney function occur while taking this medication, you must discontinue use and seek medical attention immediately. Gastrointestinal disturbances such as dyspepsia, diarrhea, nausea, and vomiting may also occur, and if symptoms are severe, it is important to consult with healthcare professionals. Long-term or excessive use of this medication may lead to auditory disturbances or muscle-related side effects, so caution is advised. Furthermore, this medication may influence certain test results, so it is vital to inform healthcare professionals about its use prior to testing. When taking this medication, it is essential to adhere to the duration and dosage advised by the physician to prevent the development of antibiotic resistance, and it is crucial to discuss potential interactions with healthcare professionals if taken alongside other medications. Finally, this medication may cause dizziness or confusion when driving or operating machinery, so caution is required.

Shock, anaphylactic symptoms, difficulty breathing, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, epigastric pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, stool discoloration, membranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, elevated total bilirubin, increased serum creatinine, increased BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, abnormal sensation, arthralgia, myalgia, olfactory disorder, tinnitus, auditory disability, hypoglycemia, tinnitus, hearing impairment, vomiting, nausea, abdominal pain, purpuric rash, acute generalized pustular psoriasis, cellulitis, candidiasis, gastroenteritis, infection, vaginal infection, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, angioedema, decreased appetite, insomnia, neuropathy, noise sensitivity, psychotic disorder, state of confusion, abnormal dreams, movement disorders, non-vestibular vertigo, drowsiness, tremors, musculoskeletal rigidity, myopathy, cardiac arrest, atrial fibrillation, premature contractions, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, elevated alanine aminotransferase, elevated aspartate aminotransferase, increased gamma-glutamyltransferase, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, papular rash, acne, Henoch-Schonlein purpura, muscle spasms, elevated blood urea, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased International Normalized Ratio, prolonged prothrombin time, urine color abnormality

This medication should be stored in a tightly sealed container to prevent exposure to air and moisture. Additionally, it should be kept in a cool, dry place away from direct sunlight, maintaining a temperature between 1°C and 30°C.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle