Nulaxon Injection 2g (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children over 12 years should receive 1～2g (potency) of ceftriaxone once daily by intravenous or intramuscular injection. In cases of severe illness or infections caused by moderately susceptible pathogens, this can be increased to 4g (potency) once daily. Elderly patients do not need a change in adult dosage. For gonorrhea treatment, a single intramuscular injection of 250mg (potency) is recommended if the pathogen is susceptible or resistant to penicillin.

Child administration

Neonates (up to 14 days old) should receive 20～50mg (potency) per Kg of body weight once daily, not exceeding 50mg (potency). Infants and children (from 15 days to 12 years) should receive 20～

This medication should not be used with calcium-containing solutions, as this can lead to dangerous precipitates when administered concurrently or mixed. Especially in neonates, administering this drug with calcium-containing solutions poses a risk of fatal precipitates in the lungs and kidneys, and should be avoided. Patients with hypersensitivity to this medication or those allergic to cephalosporins, penicillin antibiotics, and certain local anesthetics should avoid use. It may also be dangerous in premature infants or neonates with bilirubin binding issues and should not be used. Patients with severe renal dysfunction may have increased drug concentrations, necessitating dosage and interval adjustments. Various side effects, including diarrhea, rash, abnormal liver function, and decrease in blood cell counts, can occur, and immediate consultation with a doctor is required upon onset of abnormal symptoms. There is a risk of fatal allergic reactions or shock, thus thorough history taking and observation before administration is needed, along with readiness for emergency treatment. Use it only for the required duration to prevent antibiotic resistance, and regular liver and kidney function tests are important. Caution is advised when driving or operating machinery as side effects such as dizziness may occur. Pregnant or breastfeeding women should use this medication cautiously after consulting a physician, and it is not to be used in neonates or premature infants due to the risk of bilirubin encephalopathy. The elderly are at increased risk of side effects due to diminished bodily functions, thus dose and interval adjustments may be necessary. This medication may interact with other drugs, especially diuretics, aminoglycoside antibiotics, and vitamin K antagonists, therefore caution is needed when used together. The prepared solution should be used promptly, and it is advisable to use it within 6 hours at room temperature, or within 24 hours if refrigerated.

Serious side effects

• Urticaria
• severe swelling (edema)
• rash
• anaphylaxis and anaphylactoid reactions
• severe allergic reactions
• erythema multiforme
• Stevens-Johnson syndrome
• toxic epidermal necrolysis
• shock
• encephalopathy

Mild side effects

Eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes, headache, dizziness, itching, hematuria, diabetes, phlebitis, injection site pain, fever, edema, chills, increased serum creatinine, pseudomembranous colitis, nausea, vomiting, loose stools, taste disturbance, abdominal pain, loss of appetite, abdominal bloating, dyspepsia, pancreatitis, sweating, flush, palpitations, nosebleed, Clostridium difficile associated diarrhea, hypotension, stomatitis, glossitis

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. The storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius. This way, the effectiveness of the medication can be well preserved.

Appearance

White to light yellow crystalline powder filled in a colorless, transparent vial

Package unit

For domestic use - 2 grams/vial [2g/vial × 10]