Sigamet Tablet (Cimetidine)

Adult dosage

Take 400 mg orally twice a day (in the morning and at bedtime) or 800 mg once a day (at bedtime). Also, 300 mg can be taken orally four times a day (after meals and at bedtime). The dosage may be increased to 400 mg four times a day (after meals and at bedtime) (total of 1.6 g). For acute gastritis and acute exacerbations of chronic gastritis, administer 200 mg twice a day or 400 mg once a day. For patients with renal dysfunction, 300 mg may be given orally twice a day, every 12 hours. Depending on the patient's symptoms, the frequency may be increased to three times a day, every 8 hours or more, but caution is advised. In severe cases of renal dysfunction, the drug may accumulate in the body, so the frequency should be minimized according to the patient's reaction. Hemodialysis lowers blood levels of cimetidine. After hemodialysis, resume the scheduled administration of the medication.

Children's dosage

Administer orally in divided doses of 20 to 40 mg per kg of body weight per day.

Care should be taken when using this medication because glass fragments may be mixed when using glass ampoule injections, so the container must be cut carefully. Extra caution is required when used in children and the elderly. Patients with allergies or a history of hypersensitivity to cimetidine or any other components of this medication should not receive it. Additionally, patients taking dofetilide should not be administered this medication due to the increased risk of ventricular arrhythmias. Patients with impaired renal or liver function, those with a history of drug allergies, elderly patients, children under 19 years old, and patients undergoing hemodialysis should use this medication with caution. In particular, those with reduced renal function may need dosage adjustments as drug concentrations can increase. This medication may conceal symptoms of gastric cancer, so it should only be used after confirming malignancy, and patients with Helicobacter pylori infection should receive eradication treatment concurrently. Furthermore, patients with an allergy to Yellow No. 4 (Tartrazine) should be cautious. Side effects may include decreased blood cell counts, liver function abnormalities, kidney problems, allergic reactions, gynecomastia, digestive disorders, neurological symptoms, and others. If these symptoms occur, consult a healthcare professional immediately. During the use of this medication, closely observe the course of the disease, and if ineffective, switch to other treatments. Regular blood tests and assessments of liver and kidney function are important. Elderly patients or those with chronic diseases may be at an increased risk of pneumonia, so caution is needed. In addition, interactions may occur when taken with certain drugs, so patients should inform healthcare providers of any other medications they are taking. Pregnant or breastfeeding women should use this medication cautiously after consulting a physician, as it may affect the fetus or infant. In case of overdose, severe symptoms such as respiratory depression may occur, so immediate emergency treatment is required. When using the injection form of this medication, rapid intravenous injections should be avoided, and slow infusions should be performed to reduce the risk of hypotension or arrhythmias. Finally, this medication should be stored out of reach of children, and transferring it to other containers should be avoided for safety.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, generalized redness, shock, anaphylaxis-like reaction (including breathing difficulties), thrombocytopenia, leukopenia, granulocytopenia, agranulocytosis, pancytopenia, aplastic anemia, immune hemolytic anemia, jaundice, hepatitis, elevated AST and ALT indicating liver dysfunction, perivascular liver fibrosis, interstitial seizures, acute renal failure, interstitial nephritis, urinary retention, elevated BUN,

Mild side effects

• Abdominal bloating
• constipation
• diarrhea
• gynecomastia
• excessive milk secretion
• increased vaginal discharge
• erectile dysfunction
• headache
• dizziness
• drowsiness

This medication should be stored in a tightly sealed container to avoid exposure to air and should be kept at a temperature between 1 to 30 degrees Celsius (room temperature). This will help to maintain the effectiveness of the medication and ensure safe use.

Appearance

Pale green, circular film-coated tablet

Package unit

1000 tablets per bottle, 30 tablets per bottle