Clarithromycin 500mg Tablet

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) per dose twice daily; for severe infections, administer 500mg (potency) per dose twice daily. The usual treatment duration is 7～14 days. In patients with renal failure and creatinine clearance of 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) per dose twice daily. Do not administer this medicine to such patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine per dose twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Helicobacter pylori eradication in patients with duodenal ulcers: Administer 500mg (potency) of this medicine 3 times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) per dose 3 times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years or older: Same as adults Children under 12 years: Use clarithromycin dry syrup.

This medication should not be administered to patients with certain drugs or diseases. For instance, it may be dangerous for those who have hypersensitivity to this medication or allergies to macrolide antibiotics, as well as patients with cardiac arrhythmias or severely impaired liver and kidney function. Additionally, it is advisable for pregnant or lactating women not to use this medication. Serious interactions may occur when taken with certain other drugs, so consultation with a specialist is essential if other medications are being taken. When administering this medication, liver and kidney function should be regularly checked, and if any adverse reactions occur, usage should be stopped immediately and consulted with medical staff. Particularly, allergic reactions, gastrointestinal disturbances, skin rashes, auditory impairments, and central nervous system symptoms may arise, requiring careful monitoring. To prevent antibiotic-resistant bacteria, it is crucial to take the medication only during the prescribed period and not to discontinue it arbitrarily. Caution is needed as prolonged or excessive use can lead to side effects such as tinnitus and hearing loss. Finally, this medication may require caution when driving or operating machinery, so care should be taken during these activities while on treatment.

Shock, anaphylactic symptoms, difficulty breathing, convulsions, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, cramp-like upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, dysgeusia, anorexia, constipation, discoloration of stool, membranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, difficulty breathing, chest X-ray abnormality, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute sinusitis exacerbation, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash associated with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, AST elevation, ALT elevation, γ-GTP elevation, LDH elevation, ALP elevation, total bilirubin increase, anorexia, jaundice, dark urine, itching, abdominal tenderness, increased serum creatinine, increased BUN, interstitial nephritis, kidney failure, rhabdomyolysis, myalgia, weakness, increased CPK, elevated serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de Pointes, malaise, headache, taste distortion, hearing loss, paraesthesia, arthralgia, myalgia, olfactory disturbance, tinnitus, hearing impairment, hypoglycemia, rhabdomyolysis, tinnitus, hearing loss, vomiting, nausea, abdominal pain, purpuric rash, acute generalized pustular psoriasis, soft tissue infection, candidiasis, gastroenteritis, infection, vaginitis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, hypersensitivity, anaphylactic response, angioedema, anorexia, decreased appetite, hypoglycemia, insomnia, anxiety, nervousness, noise intolerance, psychotic disorder, confusional state, depersonalization, depression, disorientation, hallucination, abnormal dreams, mania, dysgeusia, headache, loss of consciousness, movement disorders, non-vestibular vertigo, drowsiness, tremors, convulsions, loss of taste, abnormal olfaction, loss of smell, vestibular vertigo, hearing impairment, hearing loss, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, abdominal distension, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, alanine aminotransferase elevation, aspartate aminotransferase elevation, gamma-glutamyl transferase elevation, liver failure, hepatocellular jaundice, rash, diaphoresis, vesicular dermatitis, itching, hives, papular rash, acne, Henoch-Schönlein purpura, muscle cramps, musculoskeletal stiffness, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, elevated serum urea, kidney failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urinary color abnormality

This medication is sensitive to light, so it should be stored in a special container that does not allow light in. Additionally, to maintain the effectiveness of the medication, it should be stored at room temperature between 15 to 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle