Clarithromycin 250 mg Tablets

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7~14 days. In patients with renal failure whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1–14), and omeprazole 40mg once daily for 28 days (days 1–28).

Child dose

Children aged 12 years or older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients who are allergic to certain components. Patients with hypersensitivity to clarithromycin or similar class of antibiotics should not take this medication. Caution should be exercised in patients with a history of heart disease or prolonged QT interval. For patients with severely impaired liver or kidney function, administration should be avoided or the dosage adjusted. Pregnant or breastfeeding women should not take this medication for safety. If any allergic reactions or severe side effects occur during treatment, immediately discontinue use and consult medical personnel. This medication has a high potential for drug interactions; inform health care providers of any other medications being taken. Special caution is needed when used together with specific heart-related drugs, statins, anticoagulants, and certain antiviral drugs. Prolonged or high-dose use of this medication may cause hearing disturbances or tinnitus, so symptoms should be carefully monitored. Children, the elderly, and immunocompromised patients have a higher risk of side effects when using this medication, so it should be used cautiously. Consult a doctor immediately if symptoms like diarrhea, abdominal pain, rash, or respiratory difficulties develop during use, as there is a risk of serious gastrointestinal conditions such as pseudomembranous colitis. In cases of overdose, proper emergency measures such as gastric lavage may be needed, as blood dialysis is not effective for drug removal. This medication should be stored away from direct sunlight and at room temperature; refrigeration is not recommended.

Shock, anaphylactic symptoms, dyspnea, convulsions, flushing, rash, itching, urticaria, mild skin flushing, angioedema, joint swelling, drug eruption, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, flatulence, diarrhea, oral mucosal erosion, upper abdominal pain, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, decreased appetite, constipation, change in stool color, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute exacerbation of acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmare, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, paresthesia, behavioral changes, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug eruption accompanied by eosinophilia and systemic symptoms, jaundice, hepatocellular or cholestatic hepatitis, increased liver enzyme levels, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, gustatory dysfunction, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular rash, vasodilation, venous thrombophlebitis at the injection site, injection site pain, inflammation at the injection site, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase levels, elevated serum lactate dehydrogenase levels, increased International Normalized Ratio, prolonged prothrombin time, abnormal urine color, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myopathy, nephritis, asthma, epistaxis, pulmonary embolism, cardiac arrest, atrial fibrillation, QT prolongation on EKG, extrasystoles, palpitations, ventricular fibrillation, myocardial infarction, cardiovascular death, changes in mental administration, obsessive behavior, hypokalemia, hypoxemia

This medication should be stored at room temperature between 1 to 30 degrees Celsius and kept in a tightly sealed container to prevent air exposure. This way, the effectiveness of the medication can be maintained for a longer duration.

Appearance

Yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle