Geotrip Tablet 40 mg (Apatinib Maleate)

Adult dose

Take 40mg orally once daily at least 1 hour before a meal or at least 3 hours after a meal. This medicine must be administered without food, and the tablet should be swallowed whole with water. This medicine may be continued until disease progression or unacceptable toxicity occurs. Temporarily interrupt treatment with this medicine in the event of NCI CTCAE grade 3 or higher, grade 2 or higher diarrhea persisting for more than 2 days despite antidiarrheal treatment, grade 2 skin reactions persisting for more than 7 days or that are intolerable, or grade 2 or higher renal impairment. When the adverse drug reaction recovers to grade 1 or lower, resume treatment with this medicine at a dose reduced by 10mg from the previously administered dose. Permanently discontinue treatment with this medicine in the event of severe bullous, blistering, or exfoliative skin symptoms, interstitial lung disease, severe hepatic impairment, persistent ulcerative keratitis, symptoms of left ventricular dysfunction, or severe or intolerable adverse reactions at a daily dose of 20mg. No dose adjustment is necessary in patients with mild (glomerular filtration rate (eGFR) 60-89mL/min) or moderate (glomerular filtration rate (eGFR) 30-59mL/min) renal impairment. For patients with severe renal impairment (glomerular filtration rate (eGFR) 15-29mL/min), a dose of 30mg once daily is recommended. Administration of this medicine is not recommended in patients with a glomerular filtration rate (eGFR) below 15mL/min or in patients undergoing dialysis. No adjustment of the starting dose is necessary in patients with mild hepatic impairment (Child Pugh A) or moderate hepatic impairment (Child Pugh B). As this medicine has not been studied in patients with severe hepatic impairment (Child Pugh C), its administration is not recommended. For patients who must receive a P-glycoprotein (P-gp) inhibitor, it should be administered with this medicine or after administration of this medicine. If the tablet cannot be swallowed whole, it may be dispersed in approximately 100ml of non-carbonated drinking water; do not use any other liquid. Do not crush this medicine. Place it in water and stir occasionally for 15 minutes until the tablet breaks into very small particles, then take the dispersion immediately. Rinse the cup used with approximately 100ml of water and drink it. This dispersion may also be administered through a feeding tube.

Child dose

The safety and efficacy of this drug have not been studied in children; therefore, its use is not recommended in pediatric patients.

This drug may cause harmful effects to the fetus if taken during pregnancy; therefore, pregnant women should not use it. Effective contraception must be used during treatment, and if pregnancy occurs or is suspected, the prescribing physician should be notified immediately. Rarely, serious skin disorders may occur, and if any blisters or rashes appear, medication should be discontinued immediately. Patients allergic to any ingredients of this medication or those with specific lactose intolerance should not take it. Patients with a history of interstitial lung disease or severely compromised liver function should use this medication cautiously and discontinue if symptoms worsen and seek treatment. There may be interactions with other medications, so caution is required, especially when combined with P-glycoprotein inhibitors or inducers. Diarrhea, skin rashes, stomatitis, etc., may commonly occur as side effects, and if these symptoms are severe, consultation with a doctor for dose adjustment or treatment may be necessary. Adequate fluid intake should be maintained during treatment; if diarrhea occurs, antidiarrheal agents should be used immediately, and medication may need to be temporarily suspended if necessary. Exposure to sunlight may worsen skin reactions; using sunscreen and wearing protective clothing is advised. If inflammation or pain in the eyes occurs, an ophthalmologist should be consulted immediately, and caution should be exercised by patients with a history of keratitis. It is safest for pregnant or lactating women to avoid this medication; nursing should be discontinued if breastfeeding. In the case of overdose, there is no specific antidote, so medication should be stopped immediately, and symptomatic treatment should be received. The effects on driving or machine operation are not known, but caution may be needed depending on symptoms.

Stevens-Johnson syndrome, toxic epidermal necrolysis, blisters, vesicles, exfoliative skin symptoms, interstitial lung disease, diarrhea, skin rash, acneiform dermatitis, stomatitis, periungual inflammation, cystitis, decreased appetite, dehydration, hypokalemia, taste disorder, conjunctivitis, dry eyes, keratitis, epistaxis, rhinorrhea, nausea, vomiting, dyspepsia, cheilitis, pancreatitis, gastrointestinal perforation, increased alanine aminotransferase, increased aspartate aminotransferase, pruritus, dry skin, erythema multiforme syndrome, nail disorders, muscle cramps, renal disorders, renal failure, fever, weight loss, pneumonia, dyspnea, pleural effusion, acute kidney injury, nausea, abdominal pain, oral ulcer formation, colitis, nail infections, nail bed infections, onychomycosis, upper respiratory tract infections, atypical pneumonia, bacterial pneumonia, acute pyelonephritis, septic shock, cough, productive cough, hemoptysis, pulmonary inflammation, pulmonary embolism, asthma, pneumothorax, pulmonary fibrosis, decreased appetite, decreased intake, asthenia, headache, dizziness, hemiparesis, cerebral infarction, hydrocephalus, seizures, back pain, limb pain, lumbar spondylolisthesis, anemia, deep vein thrombosis, pericardial effusion, orthostatic dizziness, benign paroxysmal positional vertigo, hepatotoxicity, cholelithiasis, drug-induced liver injury, liver cirrhosis, toxic hepatitis, pelvic pain, adrenal insufficiency, inappropriate secretion of antidiuretic hormone, cutaneous vasculitis, diaper dermatitis, hirsutism, neurodermatitis, nail pain, skin pain, papules, petechiae, photosensitivity reactions, psoriasis, rosacea, bacteremia, chest wall abscess, chronic sinusitis, Clostridium difficile colitis, dermatophyte infections, ear infections, herpes dermatitis, streptococcal infections, Helicobacter infections, herpes simplex, impetigo, rhinitis, urinary tract infections, pharyngitis, soft tissue infections, herpes zoster, periodontitis, tinea pedis, gastroenteritis, oral candidiasis, limb abscesses, allergic rhinitis, asphyxia, aspiration, atelectasis, laryngeal edema, nasal discomfort, nasal congestion, pharyngitis, voice disorder, hiccups, nasal ulcers, cachexia, hypercalcemia, hypophosphatemia, hypoalbuminemia, decreased blood volume, zinc deficiency, axillary pain, paroxysmal pain, gait disturbance, systemic edema, facial swelling, edema, thirst, aphasia, ataxia, burning sensations, Alzheimer's dementia, intracranial aneurysm, intracranial mass, migraine, myelopathy, normal pressure hydrocephalus, seizure-like phenomena, syncope, tremors, arthritis, spinal disc disorder, lumbar spinal canal stenosis, muscle weakness, rheumatoid arthritis, rotator cuff syndrome, increased blood bilirubin, increased blood creatine phosphokinase MB, increased blood lactate dehydrogenase, decreased blood potassium, decreased blood pressure, increased C-reactive protein, decreased carbon dioxide, increased fibrinogen D-dimer, decreased hematocrit, increased neutrophils, abnormal prothrombin time, decreased free thyroxine, increased troponin T, weight gain, phobia, adjustment disorders, anxiety disorders, bipolar disorder, depressed mood, disorientation, changes in mental state, hematuria, toxic nephropathy, azotemia, ureteral calculi, neurogenic bladder, cataracts, decreased vision, visual impairment, conjunctival hemorrhage, allergic conjunctivitis, punctate keratitis, thrombocytopenia, skin lacerations, hypertension, essential hypertension, lymphedema, ventricular tachycardia, atrial fibrillation, sinus tachycardia, tinnitus, earache, ear discomfort, external ear pain, hearing loss, cholecystitis, genital pruritus, atrophic vaginitis, genital erosion, irregular menstruation, vaginal bleeding

This medication should be stored at room temperature between 1 degree and 30 degrees Celsius, and it is important to keep it in a well-closed container that is air-tight. This helps to maintain the drug's efficacy for a longer period.

Appearance

Pale blue, film-coated tablet that is circular and biconvex on both sides

Package unit

28 tablets (7 tablets/PTP * 4 packs)