Lotrovant 20 mg (Rosuvastatin Calcium)

Adult dose

Can be taken at any time of the day, irrespective of meals. The initial dose is typically 5 mg once daily, while the maintenance dose is usually 10 mg once daily for most patients. The maintenance dose should be adjusted based on LDL cholesterol levels, therapeutic goals, and patient response at intervals of 4 weeks or more, with a maximum increase to 20 mg once daily.

Child dose

For pediatric patients aged 10 to 17 years, the dosage is 5 mg to 20 mg once daily. The dosage should be adjusted according to the individual therapeutic goals at intervals of 4 weeks or more. 10

This medication should not be used in patients who are allergic to certain components. It should not be administered in the presence of active liver disease or severe hepatic impairment. Patients with muscle disorders or related muscle issues are not suitable for this medication. Patients taking cyclosporine or those with severe renal dysfunction should also avoid this treatment. Pregnant or nursing women should not use this medication, and women of childbearing potential should employ appropriate contraception. Patients at high risk for myopathy or rhabdomyolysis should particularly avoid high-dose administration. This medication contains lactose, so patients with lactose intolerance should be cautious. Patients with a history of hepatic impairment or excessive alcohol consumption should undergo repeated liver function tests before and during treatment. If symptoms of muscle pain or weakness occur, tell your healthcare provider immediately and get tested. Treatment may need to be withheld during severe physical stress or serious illness. There may be interactions with other medications, so any concurrent medications should be disclosed to a healthcare provider. Particular caution is needed when combined with fibrate-class drugs due to the increased risk of muscle-related adverse reactions. This product can occasionally cause serious skin reactions or liver damage, so if rash or jaundice appear, use should be stopped immediately. Clinical trials and post-marketing reported side effects include headache, dizziness, digestive disorders, and myalgia, which are mostly mild and transient. In case of overdose, there is no specific antidote, so treatment should be symptomatic, and liver function and muscle enzyme tests are required. Dizziness may occur when driving or operating machinery, so caution is advised. In Asian individuals, blood concentrations may be higher, so dosage adjustments may be necessary. There is limited evidence of effects on growth and secondary sexual characteristics in children and adolescents, so cautious use is recommended.

Serious side effects

Allergic reactions including urticaria, angioedema, myopathy, rhabdomyolysis, severe allergic reactions, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms, immune-mediated necrotizing myopathy, cough, dyspnea, respiratory problems, jaundice, hepatitis, hepatic abnormalities, severe muscle weakness, ophthalmoplegia, severe edema, acute renal failure, oliguria, severe liver damage, hyperbilirubinemia, severe skin disorders

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• pruritus
• myalgia
• weakness
• hematuria
• diarrhea

This medication should be stored in a tightly closed container to protect it from air and moisture. It is best to maintain storage temperatures between 1 degree and 30 degrees Celsius.

Appearance

Pink round film-coated tablet

Package unit

30 tablets (10 tablets/Alu-Alu X3)