Kyungbocefprazole 250 mg (Cefprozil Hydrate)

Adult dose

○ Adults (13 years and older) 1) For pharyngitis and tonsillitis, which are upper respiratory tract infections, administer 500mg (potency) of cefprozil per dose every 24 hours. For acute sinusitis, administer 250mg (potency) or 500mg (potency) every 12 hours (an increase in dose is required for moderate or more severe infections). 2) For bacterial superinfection of acute bronchitis or bacterial exacerbation of chronic bronchitis, which are lower respiratory tract infections, administer 500mg (potency) of this medicine per dose every 12 hours. 3) For uncomplicated skin and soft tissue infections, administer 250mg (potency) of this medicine per dose every 12 hours [or 500mg (potency) every 24 hours], or administer 500mg (potency) every 12 hours depending on symptoms. 4) For uncomplicated urinary tract infections, administer 500mg (potency) of this medicine every 24 hours. <Duration of administration> Treatment is generally given for about 10 days; however, for pharyngitis/tonsillitis caused by Streptococcus pyogenes (Group A beta-hemolytic), administer for 10 days or longer. For uncomplicated cystitis, administer for about 7 days. ○ Patients with renal impairment 1) If creatinine clearance is 30～120mL/min, administer according to the standard dosage and administration above. 2) If creatinine clearance is 29mL/min or less, administer 50% of the standard dose at the standard dosing interval. However, some of this medicine is removed by hemodialysis, so administer it after hemodialysis is completed. Once reconstituted, store in a refrigerator and use within 14 days (syrup only).

Child dose

○ Children (2～12 years): For pharyngitis and tonsillitis, which are upper respiratory tract infections, administer 7.5mg (potency) per kg of body weight per dose every 12 hours. ○ Children (2～12 years): For uncomplicated skin and soft tissue infections, administer 20mg (potency) per kg of body weight per dose every 24 hours. ○ Infants and children (6 months～12 years): For otitis media, which is an upper respiratory tract infection, administer 15mg per kg of body weight every 12 hours. ○ Infants and children (6 months～12 years): For acute sinusitis, administer 7.5mg per kg of body weight every 12 hours. However, for moderate or more severe infections requiring an increased dose, administer 15mg per kg of body weight every 12 hours.

This drug is a cephalosporin antibiotic and should not be administered to patients with a history of allergy to cephalosporins. Patients with a history of allergy to penicillin or other drugs should use this drug cautiously. Approximately 10% of individuals with penicillin allergies may also show allergic reactions to this drug. Severely ill patients or those with impaired kidney function must verify renal status before administration and should reduce the dose if necessary. Patients with a history of gastrointestinal disease, especially colitis, should also use caution. When taking this drug, gastrointestinal disturbances such as diarrhea, nausea, vomiting, and abdominal pain may occur. Reports of liver dysfunction or hypersensitive responses such as rash and urticaria have also been noted. Symptoms affecting the central nervous system such as dizziness, headaches, and drowsiness may rarely occur, as well as kidney dysfunction or hematologic issues. Long-term use of this drug may lead to resistance or excessive growth of other bacteria, so it is advisable to use it for the minimum duration necessary for treatment. If allergic symptoms occur, immediately discontinue the drug and seek necessary emergency measures. If diarrhea occurs after antibiotic use, consider the possibility of pseudomembranous colitis and receive appropriate treatment. Caution is needed when used concurrently with other cephalosporins or diuretics as it may increase renal toxicity. It should only be used during pregnancy when absolutely necessary, and nursing mothers should consider the potential effects on the infant before use. It is not recommended for infants under 6 months of age as safety and efficacy have not been established. Elderly patients may have reduced kidney function and may require dose adjustments. This drug is excreted through the kidneys; therefore, if overdosed, it can be removed through hemodialysis. Since it may influence clinical test results, be sure to inform healthcare professionals about this point during testing.

• Diarrhea
• nausea
• vomiting
• abdominal pain
• elevated AST
• elevated ALT
• elevated ALP
• elevated bilirubin levels
• rash
• hives

This drug is sensitive to light and should be stored in a container that blocks light. Furthermore, it is important to maintain a room temperature of 1 to 30 degrees Celsius when storing the drug.

Appearance

Pale yellow oval film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle