Trazone Tablet (Itraconazole)

Adult dosage

This medicine should preferably be administered immediately after meals to increase absorption. 1. Short-term treatment This medicine continues to exert a therapeutic effect in skin tissue even after discontinuation. Therefore, it is advisable to assess the final clinical and mycological response 2～4 weeks after completing the prescribed treatment. 1) Candidal vaginitis: Administer itraconazole 200 mg twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Tinea versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital type), tinea pedis (interdigital type): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar type), tinea pedis (plantar type): Administer 100 mg once daily for 30 days or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis of the fingernails and toenails 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period. This constitutes 1 cycle. Administer up to 2 cycles for infection of the fingernails only and up to 3 cycles for infection of the toenails. 2) Continuous therapy Administer 200 mg once daily for 3 months. The therapeutic effect continues for 3 months for fingernails and 6 months for toenails after treatment ends. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplants, the oral bioavailability of this medicine may be reduced; if necessary, double the dose. Aspergillosis: 200mg once daily for 2～5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100～200mg once daily for 3 weeks～7 months. Cryptococcal meningitis: 200mg twice daily for 2 months～1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily for 6 months.

This medication can be life-threatening to patients with congestive heart failure, so it should not be used unless for the treatment of severe infections. If symptoms of heart failure develop during treatment, usage must be stopped immediately. Patients who are allergic to this medication or who have a history of impaired heart function should not take it. Additionally, serious side effects can occur with certain medications, so it is essential to consult a physician. It is safest for pregnant women or women who might become pregnant and those who are breastfeeding to avoid using this medication. Patients with impaired liver function should have regular liver function tests, as this medication can worsen liver damage, and dosage adjustments may be necessary. Caution is also necessary for patients with impaired kidney function, as dosage adjustments should be considered. This medication has many drug interactions, and concomitant administration may increase side effects or alter therapeutic effects, so all medications being taken should be reported to healthcare professionals. Symptoms such as dizziness, vision disturbances, and hearing loss can occur during administration, so caution is needed when driving or operating machinery. In the event of overdose, there is no specific antidote, so one should seek immediate medical attention for appropriate treatment. This medication should be stored out of the reach of children and kept in its original container to prevent degradation of quality.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disorder, sensory disturbance, paresthesia, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylaxis-like reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremor, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, dysphonia, cough, gastrointestinal disorder, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, kidney impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, hearing loss, ventricular premature contractions, atrial block, palpitations, increased intestinal motility, belching, glossitis, stomatitis, abdominal and lumbar pain, pancreatitis, increased serum total protein, increased total bilirubin, increased LAP, anorexia, malaise, brown urine, elevated liver enzyme levels, mucocutaneous syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Reiel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, increased BUN, positive urine protein reaction, positive urine glucose reaction, decreased libido, drowsiness, malaise, shoulder stiffness, insomnia, chest pain, elevated serum triglyceride levels, burning sensation, elevated serum uric acid levels, elevated serum potassium levels, serum sickness, angioedema, anaphylactic response, hypertriglyceridemia, tremor, visual impairment, transient or permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase activity

This medication should be stored in a sealed container to prevent air ingress, and it is best kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the efficacy and safety of the medication.

Appearance

White to off-white oval film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle