Amoxicil Tablets 625 mg (Amoxicillin-Clavulanate Potassium (4:1))

Adult dose

For Amoxicillin/Clavulanate Potassium, administer 250 mg/125 mg orally per dose, three times a day every 8 hours. In cases of severe and respiratory infections, the dose may be escalated to 500 mg/125 mg per dose. In cases of renal impairment, the dosage must be adjusted according to creatinine clearance. - Creatinine clearance 10 to 30 mL/min: administer 250 mg/125 mg or 500 mg/125 mg every 12 hours.

Child dose

For children aged 12 years or older or weighing 40 kg or more, the same dosage as adults should be administered: Amoxicillin/Clavulanate Potassium 250 mg/125 mg per dose, taken orally three times a day every 8 hours. In cases of severe and respiratory infections, dosing may need to be adjusted.

This drug is a beta-lactam antibiotic and belongs to the penicillin class. Patients with a history of allergic reactions to this drug's components or hypersensitivity to beta-lactam drugs should not use it. Particularly, it is advisable to avoid use in patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with liver function problems should also be cautious as liver dysfunction may recur upon use. Patients with poor liver function or renal impairment may have increased drug concentrations, thus dosing intervals may need to be adjusted or used cautiously. Patients with allergies, those receiving non-oral nutrition, the elderly, and patients in poor overall condition should also be cautious of possible side effects like vitamin deficiency when using this drug. Gastrointestinal symptoms such as abdominal pain, diarrhea, nausea, and vomiting may occur, and in severe cases, pseudomembranous colitis or acute pancreatitis may develop, necessitating immediate discontinuation upon symptom occurrence. Rarely, abnormal liver symptoms such as elevated liver enzymes, hepatitis, and cholestatic jaundice may appear, particularly in the elderly and males. Skin rashes, itching, and severe skin reactions (such as Stevens-Johnson syndrome) may occur, and medication should be discontinued immediately if abnormalities arise. Blood tests may occasionally reveal leukopenia, thrombocytopenia, or hemolytic anemia, so regular blood tests may be required. CNS adverse responses like agitation, anxiety, confusion, and convulsions can also rarely occur, so caution is needed if symptoms arise. Rapid deterioration of kidney function may also occur, hence regular kidney function tests should be conducted, and medication should be discontinued if abnormalities are found. This drug can disrupt the intestinal bacterial balance, leading to fungal infections like candidiasis, so appropriate measures are needed if symptoms occur. There may be a tendency for bleeding due to vitamin K deficiency when using this drug, so caution is needed if bleeding symptoms are present. When used with anticoagulants, the risk of bleeding may increase, requiring frequent checks of coagulation status and dosage adjustments. There are numerous potential interactions with other drugs, so any medications currently being taken should be disclosed to medical personnel. Use of this drug should be avoided during the first three months of pregnancy, and administration to pregnant or nursing women should be done cautiously under a physician's judgment. It is not recommended for children under 12 years of age or weighing less than 40 kg. Elderly patients may experience side effects more readily due to reduced kidney and liver function, so care should be taken with the dosage and administration intervals. In cases of overdose, symptoms such as vomiting, diarrhea, abdominal pain, drowsiness, rash, etc. may occur, and in severe instances, emergency treatment may be required. This medication should be stored in a sealed container to prevent moisture ingress and kept at a cool temperature between 1 and 25 degrees Celsius to maintain its efficacy and safety over time.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, severe rashes with high fever, blisters, peeling skin, mucous membrane pain in the mouth/eyes, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, breathing difficulties accompanying cough and fever, respiratory issues, jaundice of skin or eyes, extreme lethargy, liver abnormalities (jaundice), sudden and severe

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• appetite loss

This drug is kept in a sealed container to prevent moisture ingress, and it should be stored at a cool temperature between 1 and 25 degrees Celsius. This helps maintain the drug's effectiveness and safety for a long time.

Appearance

White or nearly white oval film-coated tablets

Package unit

40 tablets/box [4 tablets/PTP × 10]