Cabergoline Tablet (Cabergoline)

Adult dose

This medicine is taken orally. Dopamine agonists such as this medicine are better tolerated when taken with food; therefore, for all indications, take this medicine immediately after meals. 1. Prevention and suppression of lactation 1) Suppression of lactation: Take a single dose of cabergoline 1mg on the first day postpartum 2) Suppression of established lactation: Take cabergoline 0.25mg every 12 hours for 2 days (total 1mg) 2. Treatment of hyperprolactinemia: The recommended initial dose is cabergoline 0.5mg 1~2 times per week (e.g., 1/2 tablet on Monday and Thursday). Gradually increase the dose by 0.5mg of cabergoline per week, preferably at monthly intervals, until an optimal therapeutic response is achieved. The usual therapeutic dose is cabergoline 1mg per week, administered within a range of 0.5mg ~ 2mg per week. However, the maximum dose should not exceed cabergoline 4.5mg per week or 3mg per day. Adjust the dosing frequency to once or 2 or more times per week according to the patient's adherence. Tolerability when taking more than cabergoline 1mg once weekly has been evaluated in only a small number of patients; therefore, dividing doses into several administrations is recommended when taking more than cabergoline 1mg per week. During dose escalation, evaluate the patient to determine the minimum dose that produces a therapeutic response. Monitor serum prolactin levels monthly. After reaching an effective therapeutic dose, serum prolactin levels usually return to normal within 2~4 weeks. Symptoms of hyperprolactinemia may recur after this medicine is discontinued. In some patients, prolactin levels have been observed to remain low for several months. In a follow-up of a group of women who discontinued this medicine, ovulatory cycles continued for at least 6 months after discontinuation in 23 of 29 women.

This medication should not be used in certain patients. Those who are allergic to cabergoline, any ingredients in this medication, or ergot alkaloids should not take it. Patients with a history of fibrosis such as pulmonary fibrosis, pericardial fibrosis, or retroperitoneal fibrosis should also avoid this medication. Patients with severely impaired liver function, patients with pre-eclampsia, those on antipsychotic drugs, a history of postpartum psychiatric disorders, and patients diagnosed with heart valve disease should refrain from taking this medication. Patients with liver or kidney issues, patients with severe cardiovascular disease, Raynaud's syndrome, renal failure, peptic ulcers, gastrointestinal bleeding, and a history of severe psychiatric disorders should take this medication with caution. In particular, patients on antipsychotic or antihypertensive medications should be aware that symptoms of hypotension may occur. Pregnant women or women who may become pregnant should consult with healthcare professionals before taking this medication. Additionally, patients with lactose intolerance or certain genetic metabolic disorders should not take it. Side effects may occur depending on the dosage, so it is important to start with a low dose and gradually increase it. Commonly observed side effects include dizziness, headache, abdominal pain, nausea, constipation, breast pain, weakness, and fatigue. Serious side effects such as orthostatic hypotension, heart valve disease, or pulmonary fibrosis may also occur, necessitating regular check-ups. Patients with impaired liver function who are on long-term treatment may require dosage adjustments, and this medication can induce narcolepsy or sudden sleep attacks, so caution is needed when driving or operating machinery. Impulse control disorders may occur, so patients and caregivers should closely monitor for changes in behavior. Pregnant women or those planning to become pregnant should avoid taking this medication and should avoid pregnancy for at least one month after discontinuation. As this medication acts on dopamine receptors, co-administration with dopamine antagonists or certain antibiotics may reduce its effectiveness or increase side effects. Therefore, caution should be exercised to avoid taking these medications concurrently. The safety and efficacy for children or adolescents under 19 years have not been confirmed, and information regarding the elderly is also limited. Symptoms of overdose may include vomiting, hypotension, and mental confusion, and medical assistance should be sought immediately.

• Postural hypotension
• finger vascular spasms
• syncope
• lower limb cramps
• muscle weakness
• hair loss
• pruritus
• rash
• allergic skin reactions
• decreased hemoglobin levels

This medication is sensitive to light and should be stored in a container that blocks light. Additionally, it is important to store it at room temperature, specifically below 25 degrees Celsius, to maintain its effectiveness.

Appearance

White rectangular tablet with a score line

Package unit

24 tablets/bottle