Hikra Tablet 375 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

Adults and children aged 12 or over or weighing 40 kg or more: Amoxicillin/Clavulanate potassium as 250 mg/125 mg once three times daily at 8-hour intervals. In cases of severe and respiratory infections, the dosage may be increased to 500 mg/125 mg at once. In patients with renal impairment, dosage will be adjusted according to creatinine clearance. - Creatinine clearance 10 ～ 30 mL/min: 250 mg of Amoxicillin every 12 hours orally.

Child dose

Children aged 12 or over or weighing 40 kg or more should follow the same dosage as adults. Children with renal impairment should have their dosage adjusted accordingly.

This medication should not be used in patients with hypersensitivity to beta-lactam antibiotics. Those with a history of allergic reactions like anaphylaxis or severe skin reactions should be especially cautious. It is also advisable to avoid use in patients with specific viral infections like infectious mononucleosis or lymphocytic leukemia due to an increased risk of rash. Patients with a history of liver dysfunction should be careful, as this medication may cause liver damage to recur. Patients with impaired liver function or moderate to severe renal impairment may require adjustments to dosing intervals or doses due to increased drug concentrations. Allergy-prone individuals or patients with gastrointestinal symptoms such as vomiting or diarrhea should use with caution to ensure proper drug absorption. During treatment, gastrointestinal symptoms such as diarrhea, abdominal pain, and vomiting may occur, and in rare cases, serious side effects like hepatitis or severe skin rash may develop. If such symptoms occur, the medication should be immediately discontinued and a physician consulted. Long-term use of this medication may lead to the emergence of resistant bacteria, so it is important to take it only for the minimum duration recommended by a physician. Additionally, in cases of a history of hypersensitivity to penicillin antibiotics, serious allergic reactions such as anaphylactic shock may occur, so patients should be monitored closely after administration. Pregnant or breastfeeding women should use this medication only under the guidance of a physician, as it may have effects on the fetus or infant. It is especially advisable to avoid it during the first trimester of pregnancy. Elderly or pediatric patients may be at higher risk for side effects due to decreased physical function or lack of experience, requiring careful dose adjustments and monitoring. This medication can interact with other drugs, so it is essential to inform the physician or pharmacist of any other medications currently being taken. Caution is especially needed when taken in conjunction with anticoagulants, certain antibiotics, or anti-inflammatory drugs. In the event of overdose, gastrointestinal symptoms, renal impairment, or allergic reactions may manifest, and immediate medical assistance should be sought. Store this medication in a sealed container to prevent moisture, and keep it in a cool place between 1 and 25 degrees Celsius. Care should be taken not to arbitrarily discontinue or extend the duration of use without a physician's direction.

Serious side effects

Urticaria, severe swelling, chest tightness, breathing difficulties, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in oral or ocular mucosa, difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urinary changes.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medication should be stored in a sealed container to prevent moisture and kept in a cool place between 1 and 25 degrees Celsius. This will help maintain the medication's effectiveness safely.

Appearance

A white or almost white oval film-coated tablet.

Package unit

80 tablets/box [8 tablets/PTPX10], 100 tablets/box [10 tablets/PTPX10]