M-Solun Tablets (Methylprednisolone)

Adult dosage

The initial dose may vary from 4mg to 48mg of methylprednisolone per day, depending on the symptoms of the specific disease. In general, a low dose is sufficient for less severe conditions, but a high initial dose may be required in certain patients. The initial dose should be maintained or adjusted until a satisfactory response is achieved. If satisfactory clinical results are not obtained after a reasonable period, discontinue treatment and switch to another appropriate therapy. The dose must be determined individually according to the various diseases being treated and the patient's response. After an adequate response is achieved, determine the appropriate maintenance dose by reducing the initial dose at suitable intervals until the lowest dose that maintains an adequate clinical response is reached. Continuous monitoring of the dose is required. Situations that may require dose adjustment include improvement or worsening of the disease, the individual patient's response to the medication, and the effect on the patient of exposure to stressful circumstances that are not directly related to the symptoms of the disease being treated. In the latter case, it may be necessary to increase the dose for a period sufficient to satisfactorily manage the patient's condition. After long-term treatment, gradual dose reduction is recommended when discontinuing the medication. Treatment of acute exacerbations of multiple sclerosis is effective with prednisolone 200mg daily for 1 week, followed by prednisolone 80mg every other day for 1 month (4mg of methylprednisolone is equivalent to 5mg of prednisolone). Alternate-day therapy means administering twice the daily dose on one morning every 2 days. The initial suppressive dose should be continued until a satisfactory clinical response is achieved, usually for 4 to 10 days for many allergic and collagen diseases. Once control is achieved, ① Switch to ADT and gradually reduce the amount of corticosteroid given every other day. ② Reduce the daily corticosteroid dose to the minimum effective level as soon as possible, according to disease control, and then switch to an alternate-day schedule. In theory, option ① is preferable. If this is difficult, it is preferable to administer 3 or even 4 times the daily dose every other day rather than simply doubling the daily dose. Once the patient is controlled again, attempt to reduce the dose to the lowest level. The adrenal cortex is most active from 2 a.m. to 8 a.m. and least active from 4 p.m. to midnight. When administered during the period of peak activity (morning), exogenous corticosteroids suppress adrenal cortical activity the least.

This drug should not be administered to certain patients. For example, patients who are allergic or hypersensitive to this drug or its components, or those with infections or systemic fungal infections without appropriate antimicrobials may experience worsening infections. Additionally, it should not be administered to patients with herpes simplex, shingles, chickenpox, or those receiving live vaccines. Since it contains lactose, individuals with lactose intolerance or related genetic disorders should refrain from taking it. This medication should be administered with caution to patients with conditions such as glaucoma, tuberculous disease, cataracts, hypertension, thrombosis, peptic ulcers, psychosis, osteoporosis, diabetes, renal failure, hypothyroidism, fatty liver, myasthenia gravis, elderly patients, epilepsy, and ulcerative colitis, as it may exacerbate their symptoms. During the use of this drug, symptoms such as edema, increased blood pressure, muscle weakness, osteoporosis, gastrointestinal problems, skin changes, neurological symptoms, endocrine abnormalities, increased eye pressure, and heightened infection risk may occur, so symptoms should be carefully monitored. Long-term use may lead to adrenal insufficiency, and sudden discontinuation can cause severe withdrawal symptoms, so the dosage should be gradually reduced. There may also be a decreased resistance to infections, so special precautions should be taken to avoid exposure to infectious diseases such as chickenpox or measles. This drug may interact with various other drugs, so it is essential to consult a doctor or pharmacist if other medications are being taken, especially when used with drugs that may induce cardiac arrhythmias, anticoagulants, hypoglycemic agents, or diuretics. Women who are pregnant or may become pregnant should use this drug with caution as it may affect the fetus, and breastfeeding women should discontinue breastfeeding. In children, growth delays may occur, so the minimum effective dose should be used and growth should be closely monitored; likewise, elderly patients are at higher risk for adverse effects and should be treated and monitored cautiously.

Edema, sodium retention, potassium loss, fluid retention, hypokalemic alkalosis, congestive heart failure, hypertension, myasthenia, aseptic necrosis of femoral and humeral epiphyses, steroid myopathy, muscle wasting, pathologic fractures of the pelvis, osteoporosis, spinal compression fractures, arthralgia, tendon rupture, increase in ALT, increase in AST, increase in ALP, nausea, thirst, vomiting, abdominal pain, loss of appetite, increased appetite, peptic ulcer, abdominal distension, pancreatitis, esophagitis, diarrhea, delayed wound healing, facial erythema, thin and fragile skin, abnormal sweating, petechiae, ecchymosis, skin reaction suppression, purpura, acne, hirsutism, hair loss, pigmentation, papilledema, increased intracranial pressure, seizures, dizziness, headache, insomnia, euphoria, depression, Cushing's syndrome, menstrual irregularities, growth suppression in children, latent diabetes symptoms, secondary adrenal insufficiency, pituitary unresponsiveness, reduced glucose tolerance, increased requirements for insulin or oral hypoglycemic agents, suppression of adrenocorticotropic hormone secretion, increased intraocular pressure, glaucoma, posterior subcapsular cataract, secondary eye infections, central serous chorioretinopathy, retinal disorders, proptosis, negative nitrogen balance, immune system disorders, allergic reactions, shock, urticaria, anaphylactic reaction, hypersensitivity reaction

This drug should be stored in a tightly sealed container to prevent exposure to air or moisture. It is best to maintain storage temperatures between 1 degree and 30 degrees Celsius at room temperature.

Appearance

White round tablets

Package unit

30 tablets/bottle, 500 tablets/bottle