Clarithromycin 250 mg Tablets

Adult dosage

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual treatment duration is 7～14 days. In patients with renal impairment and a creatinine clearance of 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer for more than 14 days in these patients. Mycobacterial infections: Administer 500mg (potency) twice daily. In this case, it must be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer this drug 500mg (potency) three times daily in combination with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for an additional 14 days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14) and omeprazole 40mg once daily for 28 days (days 1～28).

Children's dosage

Children aged 12 years and older: Same as adults Children under 12 years of age: Use clarithromycin dry syrup.

This drug should not be used in certain patients. For example, patients allergic to the ingredients in this drug or who have had hypersensitivity reactions to similar antibiotics should not take it. It is also safe to avoid in patients with certain heart diseases or severe liver or kidney dysfunction. Women who are pregnant or breastfeeding should not take this drug, and it can be dangerous when taken with certain other medications, so it is essential to consult a doctor. When using this drug, caution should be taken for patients with weak liver and kidney function, heart disease, and the elderly. If taking other antibiotics or certain medications, there may be drug interactions, so medical consultation is required. This drug can rarely cause serious allergic reactions, gastrointestinal disturbances, liver dysfunction, kidney dysfunction, skin rashes, and other side effects. Therefore, if abnormal symptoms occur during use, inform a doctor immediately. In particular, if symptoms such as difficulty breathing, rash, severe abdominal pain, or persistent diarrhea occur, treatment should be sought immediately. To prevent the occurrence of resistant bacteria, it is crucial to verify the susceptibility of the infecting bacteria and administer the drug only for the necessary period. Since antibiotic use can disrupt the balance of intestinal bacteria, if symptoms such as diarrhea persist, it is advisable to consult healthcare professionals. Pregnant or breastfeeding women should not take this drug, and the use in children should be carefully considered based on age. Caution is needed when driving or operating machinery during the use of this drug, as dizziness or confusion may occur. In cases of overdose, symptoms such as vomiting, abdominal pain, and mental disturbances may arise, requiring an immediate visit to a medical facility, and consultation with a specialist is necessary due to potential interactions with other medications.

Shock, anaphylactic symptoms, shortness of breath, seizures, flushing, rash, itching, hives, skin flushing, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, discomfort, gas retention, diarrhea, oral ulcers, upper abdominal pain, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stools, pseudomembranous colitis, hemorrhagic colitis, fever, cough, abnormal chest X-ray findings, eosinophilia, eosinophilic lung infiltration, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, tremors, paresthesia, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug-induced rash (DRESS), jaundice, hepatocellular hepatitis, cholestatic hepatitis, elevated liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, elevated γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, loss of appetite, dark urine, pruritus, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, weakness, elevated CPK, elevated serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, malaise, headache, gustatory disturbance, hearing loss, paresthesia, arthralgia, myalgia, olfactory disorders, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, acute generalized exanthematous pustulosis (AGEP), leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, vascular edema, decreased appetite, insomnia, neurosensitivities, noise sensitivity, psychotic disorder, confusion, non-vertiginous dizziness, drowsiness, tremors, movement disorders, loss of consciousness, seizures, olfactory disturbances, vestibular dizziness, hearing loss, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, nosebleeds, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal rigidity, myopathy, elevated serum creatinine, elevated blood urea nitrogen, nephritis, injection site phlebitis, injection site pain, injection site inflammation, fever, weakness, chest pain, chills, fatigue, abnormal albumin-globulin ratio, elevated serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color

This drug is sensitive to light, so it should be stored in a light-resistant sealed container. Additionally, to maintain the drug's effectiveness, it is important to store it at room temperature between 15 and 30 degrees Celsius.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 200 tablets/bottle