Tagmetin Tablet (Cimetidine)

Adult dosage

As cimetidine, administer 400 mg orally twice a day (morning and at bedtime) or 800 mg once daily at bedtime. Additionally, 300 mg can be administered four times daily (after meals and at bedtime). Doses may be increased up to 1.6 g by administering 400 mg four times a day (after meals and at bedtime). For the improvement of gastric mucosal lesions during acute exacerbations of acute and chronic gastritis, 200 mg can be administered twice daily or 400 mg once daily.

Children's dosage

Administer 20 to 40 mg orally divided by kg body weight per day.

This medication should be handled very carefully when cutting the glass ampule container for infusion, as glass shards may mix with the solution. Care should be taken especially when used in children or the elderly. This medication should not be administered to patients with hypersensitivity to cimetidine or any other components of this medication, or those with a history of such reactions. Additionally, it should not be given to patients on dofetilide due to increased risk of cardiac arrhythmias. Patients with renal or hepatic dysfunction, those with a history of drug hypersensitivity, the elderly, children under 19 years of age, and those undergoing hemodialysis should be carefully monitored and dose adjustments may be necessary when administering this medication. Symptoms of gastric cancer may be masked by this medication, so it should only be used after confirming malignancy status, and in cases of Helicobacter pylori infection, it should be used in conjunction with bacterial eradication therapy. Rarely, this medication may cause various side effects including decreased blood cell count, liver dysfunction, kidney impairment, hypersensitivity, endocrine disorders, gastrointestinal symptoms, neuropsychiatric symptoms, and skin rashes; patients should consult healthcare professionals immediately if any abnormal symptoms occur. If there is no therapeutic effect or if adverse reactions occur, the course of the disease should be closely monitored to switch to other treatment options if needed. Particularly in elderly or chronically ill patients, there may be an increased risk of pneumonia, thus caution is warranted. This medication may interact with several drugs; therefore, dose adjustment and careful monitoring are required when combined with warfarin, midazolam, diazepam, propranolol, etc. It can also inhibit specific enzymes, altering the blood levels of other drugs, thus patients must inform healthcare professionals of any concomitant medications. Women who are pregnant or may become pregnant should carefully consider the administration of this medication, as its effects on the fetus have not been fully confirmed. Nursing mothers should be cautious as this medication is excreted in breast milk, and may need to discontinue breastfeeding or be attentive. Safety in pediatric use has not been sufficiently established, so it should only be used when there is a therapeutic necessity. In elderly patients, renal function decline may lead to elevated blood levels, thus dosages should be reduced or dosing intervals increased. In cases of overdose, severe symptoms like respiratory depression may occur, requiring immediate emergency treatment. When used as an injectable, rapid intravenous injection may lead to arrhythmias or hypotension, so it should be administered slowly. This medication should be kept out of reach of children, and transferring it to other containers should be avoided as it may adversely affect its quality.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rashes with fever, blisters, skin peeling, pain in mucous membranes of the mouth or eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever, jaundice (yellowing of skin or eyes), extreme fatigue, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination issues

Mild side effects

• Rarely
• leukopenia
• agranulocytosis
• thrombocytopenia
• pancytopenia
• aplastic anemia
• hepatitis
• elevated AST/ALT
• interstitial nephritis
• acute renal failure

This medication is sensitive to light and should be stored in a container that does not allow light to pass through. Additionally, it is recommended to store the medication at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain its effectiveness and safety.

Appearance

Pale green pentagonal tablet

Package unit

1000 tablets/bottle