Amotin Tablet 375 mg (Amoxicillin Trihydrate · Clavulanate Potassium)

Adult dose

Adults and children aged 12 years and older or weighing more than 40 kg should take Amoxicillin/Clavulanate Potassium as 250 mg/125 mg three times a day at 8-hour intervals orally. In cases of severe or respiratory infections, the dose may be increased to 500 mg/125 mg once. In cases of renal impairment, the dosage should be adjusted according to creatinine clearance. - Creatinine clearance above 30 mL/min: No dosage adjustment needed

Child dose

Pediatric patients should receive adjusted doses as per the adult administration method.

This drug is a penicillin-type antibiotic, and it is important not to use it in certain patients. First, patients who have experienced a severe allergic reaction to this drug's components or to beta-lactam antibiotics should not take this drug. Additionally, caution should be exercised in patients with viral infections accompanied by infectious mononucleosis or lymphocytic leukemia, as the risk of side effects such as rashes is higher. Patients with a history of liver function issues should also be cautious as liver damage may recur. Patients with impaired liver function or severe kidney disease may have higher concentrations of this drug, so the dosing interval may need to be adjusted. Patients who are hypersensitive or have gastrointestinal symptoms, such as vomiting or diarrhea, also need to be careful when taking this drug. Gastrointestinal side effects such as diarrhea, abdominal pain, and nausea may occur during treatment, and in severe cases, complications such as pseudomembranous colitis may arise. Signs of liver dysfunction may also occur, so elderly patients over 60 years or males should be closely monitored. Rarely, skin rashes, itching, and severe allergic reactions such as Stevens-Johnson syndrome may occur; if any unusual symptoms appear, use should be stopped immediately. Blood-related adverse reactions such as leukopenia or anemia have been reported, and neurological issues like anxiety, confusion, and seizures may rarely occur. This drug is excreted through the kidneys, so patients with poor kidney function need regular checks. Additionally, a disruption in intestinal flora can lead to infections like candidiasis or stomatitis, so patients should consult a doctor if symptoms appear. This drug can interact with other medications, particularly anticoagulants, gout medications, and some antibiotics, so care is needed when used together. Women who are pregnant or nursing should consult a doctor before use, especially it is advisable not to take this drug in the first three months of pregnancy. When administering to children or the elderly, doses should be adjusted and the condition monitored closely. In case of overdose, gastrointestinal symptoms, renal failure, rashes, and seizures may occur, so appropriate treatment should be sought immediately at a medical facility. This drug should be stored in a dry place below 25 degrees Celsius and should not be used for a long period without a doctor's guidance.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweats, paleness, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, jaundice (yellowing of skin or eyes), profound malaise, liver abnormalities (jaundice), sudden and extremely severe

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This drug is contained in a sealed container to prevent moisture and should be stored at a cool temperature between 1 and 25 degrees Celsius. It is important to avoid direct sunlight and not to place it in excessively hot or cold places.

Appearance

White or almost white oval film-coated tablet.

Package unit

100 tablets/box (10 tablets/PTP x 10)