Clarice Tablet 250 mg (Clarithromycin)

Adult dose

Adults: The usual dose is 250mg (potency) of clarithromycin twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half. That is, administer 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to such patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it must be administered in combination with other antimycobacterial agents such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcer: Administer 500mg (potency) of this medicine three times daily with omeprazole 40mg once daily for 14 days, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children aged 12 years and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients who are allergic to certain components. Patients with hypersensitivity reactions to clarithromycin or similar class antibiotics should not be administered this drug. Patients taking specific heart-related medications face risks of cardiac side effects and should not use this drug concurrently. Patients with arrhythmias or severe liver disease should also avoid this drug. For patients with significantly impaired kidney function, some formulations of this drug should not be used. Pregnant or breastfeeding women should not take this medication. Patients with central nervous system infections are also excluded from treatment. This drug contains lactose and should not be used in patients with lactose intolerance. Patients with liver or kidney dysfunction require dose adjustment or careful monitoring when using this medication. Elderly patients or those with heart disease should be cautious due to higher risks of side effects. Patients taking other specific antibiotics or medications should consult healthcare professionals due to potential interactions. This drug may rarely cause severe allergic reactions, skin disorders, liver dysfunction, or kidney problems; if any unusual symptoms occur, the medication should be stopped immediately, and a doctor should be consulted. If diarrhea or abdominal pain persists during antibiotic use, it may indicate a serious side effect such as pseudomembranous colitis, and healthcare providers should be notified immediately. Long-term or high-dose use of this medication may result in hearing loss or tinnitus, which may be reversible upon discontinuation. Co-administration with other medications may lead to changes in drug concentrations or increased side effects; thus, it's vital to inform healthcare professionals about all current medications. Pregnant or breastfeeding individuals should avoid this drug, and if absolutely necessary, they should consult with a specialist. Children and the elderly may react differently to the medication, so special caution is required. In case of overdose, gastrointestinal disturbances or central nervous system abnormalities may occur, necessitating immediate visit to a healthcare facility. This drug should be stored away from direct sunlight at room temperature, and refrigeration is not recommended.

Shock, anaphylactic symptoms, breathlessness, convulsions, erythema, rash, itching, urticaria, skin erythema, angioedema, joint swelling, drug rash, abdominal bloating, nausea, vomiting, indigestion, abdominal pain, discomfort, gas retention, diarrhea, oral mucosal erosion, upper abdominal pain, convulsive types, dry mouth, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, loss of appetite, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, abdominal pain, frequent diarrhea, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltrates, interstitial pneumonia, chronic bronchitis, acute maxillary sinusitis, eosinophilia, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucination, psychosis, depersonalization, convulsions, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, elevated ALP, increased total bilirubin, loss of appetite, dark urine, itching, abdominal tenderness, elevated serum creatinine, elevated BUN, interstitial nephritis, renal failure, rhabdomyolysis, myalgia, malaise, elevated CPK, increased serum myoglobin, elevated urinary myoglobin, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbances, tinnitus, hearing impairment, hypoglycemia, tinnitus, hearing loss, vomiting, purpuric rash, acute generalized pustular dermatitis, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, angioedema, loss of appetite, hypoglycemia, insomnia, anxiety, psychotic disorder, confusion state, depersonalization, depression, disorientation, hallucination, abnormal dreams, mania, taste disturbance, headache, loss of consciousness, movement disorders, non-vestibular vertigo, drowsiness, tremor, convulsions, loss of taste, abnormal olfaction, loss of smell, vestibular vertigo, hearing loss, deafness, cardiac arrest, atrial fibrillation, ECG QT prolongation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, diarrhea, vomiting, indigestion, nausea, abdominal pain, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, stomatitis, glossitis, abdominal distension, constipation, dry mouth, belching, bloating, acute pancreatitis, tongue discoloration, dental discoloration, abnormal liver function tests, bile stasis, hepatitis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyltransferase, liver failure, hepatocellular jaundice, rash, hyperhidrosis, vesicular dermatitis, itching, urticaria, papular rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash, acne, Henoch-Schönlein purpura, acute generalized pustular dermatitis, muscle cramps, musculoskeletal stiffness, myalgia, rhabdomyolysis, myopathy, elevated serum creatinine, increased blood urea nitrogen, renal failure, nephritis, injection site phlebitis, injection site pain, injection site inflammation, malaise, fever, asthenia, chest pain, chills, fatigue, altered albumin-globulin ratio, elevated serum alkaline phosphatase, increased serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, urine color abnormalities, gastrointestinal symptoms, changes in mental status, obsessive behavior, hypokalemia, hypoxemia

This medication may be sensitive to air and moisture, so it should be stored in a tightly closed container. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius. This will help preserve the medication's effectiveness for a longer period.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle