Daewoong Bio Clarithromycin Tablet 500mg (Clarithromycin)

Adult dose

Adults: The usual dose of clarithromycin is 250mg (potency) twice daily. For severe infections, administer 500mg (potency) twice daily. The usual duration of treatment is 7～14 days. In patients with renal impairment whose creatinine clearance is 30mL/min or less, the dose should be reduced by half: 250mg (potency) once daily, or, for severe infections, 250mg (potency) twice daily. Do not administer this medicine to these patients for more than 14 days. Mycobacterial infections: Administer 500mg (potency) of this medicine twice daily. In this case, it should be administered in combination with other antimycobacterial agents, such as ethambutol, clofazimine, and rifampin. Eradication of Helicobacter pylori in patients with duodenal ulcers: Administer 500mg (potency) of this medicine three times daily for 14 days in combination with omeprazole 40mg once daily, followed by omeprazole 40mg once daily for 14 consecutive days. That is, administer clarithromycin 500mg (potency) three times daily for 14 days (days 1～14), and omeprazole 40mg once daily for 28 days (days 1～28).

Child dose

Children 12 years of age and older: Same as adults. For children under 12 years of age, use clarithromycin dry syrup.

This medication should not be used in patients who are allergic to certain components or have had hypersensitivity reactions to this or similar classes of antibiotics. Furthermore, it should not be administered to patients with severe abnormalities in heart rhythm or liver and kidney function, and it is contraindicated in pregnant or breastfeeding women. Patients with compromised liver and kidney function, those with heart diseases, elderly patients, and those on other antibiotics or specific medications should use this drug with caution. While on treatment, it is important to closely monitor for various side effects, including allergic reactions, gastrointestinal issues, respiratory abnormalities, blood disorders, central nervous system disturbances, skin rashes, liver dysfunction, and kidney dysfunction. If severe allergic reactions or skin adverse reactions occur, administration should be immediately discontinued, and appropriate treatment should be sought. This medication has a high potential for drug interactions; therefore, patients must inform their doctor or pharmacist about any other medications they are taking. Concurrent use with certain drugs may increase risks for heart rhythm abnormalities, muscle issues, and blood sugar changes. It is safer for pregnant or breastfeeding women to avoid this medication, and if unavoidable, breastfeeding should be discontinued. Children and elderly patients require special attention when using this medication, particularly as children's usage may be limited based on age. Long-term or excessive use of this medication can lead to auditory issues or tinnitus, hence immediate consultation with medical personnel is advised if any abnormal symptoms arise. Finally, to prevent the development of drug resistance, it is important to verify sensitivity to the infectious organism and use the drug only for the necessary duration. During treatment, if persistent diarrhea or abdominal pain occurs, patients should immediately inform healthcare personnel and receive appropriate measures. Exercise caution when driving or operating machinery, as this medication may induce dizziness or confusion.

Shock, anaphylactic symptoms, difficulty breathing, seizures, flushing, rash, itching, hives, skin redness, angioedema, joint swelling, drug rash, abdominal distension, nausea, vomiting, dyspepsia, abdominal pain, malaise, gas retention, diarrhea, oral mucosal erosion, epigastric pain, cramping, thirst, transient tooth discoloration, pancreatitis, increased amylase, taste disturbance, anorexia, constipation, discoloration of stool, pseudomembranous colitis, hemorrhagic colitis, blood in stool, fever, cough, abnormal chest X-ray, eosinophilia, eosinophilic pulmonary infiltration, interstitial pneumonia, chronic bronchitis, acute sinusitis, thrombocytopenia, pancytopenia, hemolytic anemia, leukopenia, agranulocytosis, dizziness, depression, loss of taste, loss of smell, anxiety, insomnia, nightmares, tinnitus, confusion, disorientation, hallucinations, psychosis, depersonalization, tremors, numbness, behavioral changes, manic behavior, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic purpura, drug rash associated with eosinophilia and systemic symptoms, jaundice, hepatocellular hepatitis, cholestatic hepatitis, increased liver enzymes, liver dysfunction, liver failure, fulminant hepatitis, elevated AST, elevated ALT, increased γ-GTP, elevated LDH, increased ALP, elevated total bilirubin, increased serum creatinine, elevated BUN, interstitial nephritis, kidney failure, rhabdomyolysis, oliguria, glossitis, stomatitis, oral candidiasis, QT prolongation, ventricular tachycardia, Torsades de pointes, fatigue, headache, taste distortion, hearing loss, paresthesia, arthralgia, myalgia, olfactory disturbance, hypoglycemia, tinnitus, hearing impairment, purpuric rash, acute generalized pustular exanthema, cellulitis, candidiasis, gastroenteritis, infection, vaginal infection, erythema multiforme, leukopenia, neutropenia, thrombocytosis, agranulocytosis, thrombocytopenia, anaphylactic reaction, angioedema, decreased appetite, insomnia, neuroirritability, loud noise sensitivity, psychotic disorder, confusional state, abnormal dreams, movement disorders, non-vestibular dizziness, drowsiness, tremor, vestibular dizziness, hearing loss, cardiac arrest, atrial fibrillation, ectopic beats, palpitations, vasodilation, asthma, epistaxis, pulmonary embolism, esophagitis, gastroesophageal reflux disease, gastritis, rectal pain, belching, bloating, tongue discoloration, tooth discoloration, abnormal liver function tests, cholestasis, elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated gamma-glutamyl transferase, hepatocellular jaundice, vesicular dermatitis, hyperhidrosis, papular rash, acne, Henoch-Schonlein purpura, muscle cramps, musculoskeletal stiffness, myopathy, nephritis, phlebitis at injection site, pain at injection site, inflammation at injection site, fever, myasthenia, chest pain, chills, fatigue, abnormal albumin-globulin ratio, increased serum alkaline phosphatase, elevated serum lactate dehydrogenase, increased international normalized ratio, prolonged prothrombin time, abnormal urine color, changes in mental administration, obsessive behavior, hypokalemia, hypoxemia

This medication is sensitive to light and should be stored in a container that blocks light. Additionally, it should be kept at room temperature between 1 and 30 degrees Celsius. Proper storage helps to maintain the drug's effectiveness.

Appearance

Yellow rectangular film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle