Glotra Tablet (Itraconazole Solid Dispersion)

Adult dose

To increase absorption, it is preferable to administer this medication immediately after a meal. 1. Short-term treatment 1) Candidal vaginitis: Administer 200 mg of itraconazole twice daily (morning and evening) for 1 day, or 200 mg once daily for 3 days. 2) Pityriasis versicolor: Administer 200 mg once daily for 7 days. 3) Tinea corporis, tinea cruris: Administer 100 mg once daily for 15 days. 4) Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100 mg once daily for 15 days. 5) Tinea manuum (palmar), tinea pedis (plantar): Administer 100 mg once daily for 30 days, or 200 mg twice daily for 7 days. 6) Oral candidiasis: Administer 100 mg once daily for 15 days. 7) Fungal keratitis: Administer 200 mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200 mg twice daily for 1 week, followed by a 3-week drug-free period. This constitutes 1 cycle. Administer up to 2 cycles for infection of the fingernails only, and up to 3 cycles for infection of the toenails. 2) Continuous therapy Administer 200 mg once daily for 3 months. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia or AIDS, or those who have undergone organ transplantation, the oral bioavailability of this medication may be reduced. If necessary, administer twice the dose. Aspergillosis: 200mg once daily, for 2～5 months. For invasive or disseminated disease, increase the dose to 200mg twice daily. Candidiasis: 100～200mg once daily, for 3 weeks～7 months Cryptococcal meningitis: 200mg twice daily, for 2 months～1 year Maintenance therapy: 200mg once daily Paracoccidioidomycosis: 100mg once daily, for 6 months

This medication poses a risk that can be life-threatening to patients with compromised heart function or a history of heart failure, and should not be administered in such cases. If symptoms of heart failure occur during treatment, discontinue the medication immediately. Patients with hypersensitivity to this medication or allergies to its components should avoid it. Additionally, serious side effects can occur when taken with certain medications, so consultation with a doctor or pharmacist is essential if other medications are being taken. Pregnant women or those who may become pregnant, as well as nursing mothers, should not take this medication and should suspend breastfeeding during treatment. As this medication is primarily metabolized in the liver, patients with poor liver function must undergo liver function tests before taking it, and dosage adjustments may be necessary. Patients with impaired kidney function should also be cautious and may require dosage adjustments. This medication is poorly absorbed in low-acid conditions; therefore, when taking medications that reduce stomach acidity, it is recommended to take it with acidic drinks. Headaches, nausea, abdominal pain, and other symptoms may occur during treatment; if severe skin rashes or allergic reactions develop, discontinue use and consult a medical professional. This medication may cause dizziness, vision changes, or hearing loss while driving or operating machinery, so caution is advised. There is no specific antidote for overdose, so symptomatic treatment is required, and this medication is not removed by hemodialysis. Keep out of reach of children and store medications in their original containers to prevent misuse or deterioration of quality.

headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory tract infection, leukopenia, hypersensitivity, taste disorder, sensory disturbance, paresthesia, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorders, edema, granulocytopenia, thrombocytopenia, anaphylactic-like reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech disorders, coughing, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, hyperhidrosis, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, alanine aminotransferase elevation, aspartate aminotransferase elevation, serum alkaline phosphatase elevation, serum lactate dehydrogenase elevation, serum urea elevation, gamma-glutamyl transferase elevation, liver enzyme elevation, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, diplopia, visual impairment, temporary or permanent hearing loss, ventricular ectopic beats, atrioventricular block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal pain in the lower back, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, decreased appetite, malaise, brown urine, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Reye's syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urine protein test, positive urine glucose test, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglycerides, burning sensation, elevated serum uric acid, elevated serum potassium, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremors, visual impairment, temporary or permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, elevated serum creatine phosphokinase

This medication should be stored in a sealed container to prevent exposure to air and moisture, and kept at room temperature between 1 and 30 degrees Celsius. This will help maintain the drug's efficacy and prevent degradation.

Appearance

White or off-white round film-coated tablet

Package unit

28 tablets/bottle, 100 tablets/bottle