Vykra Duo Syrup (Amoxicillin Trihydrate & Clavulanic Acid Potassium)

Adult dose

For mild to moderate infections such as recurrent tonsillitis, upper respiratory infections, lower respiratory infections, urinary tract infections, and skin/soft tissue infections, take 25 mg/3.6 mg per kg of body weight divided into two doses daily. For severe infections such as otitis media, sinusitis, lower respiratory infections like bronchopneumonia, and urinary tract infections, take 45 mg/6.4 mg per kg of body weight divided into two doses daily. To minimize potential gastrointestinal intolerance,

Child dose

The 7:1 syrup is not suitable for children under 2 months of age. Pediatric patients with renal impairment should not use the 7:1 syrup. To minimize potential gastrointestinal intolerance, administer at the beginning of meals.

This drug is a beta-lactam antibiotic, belonging to the penicillin group. This drug should not be administered to patients with hypersensitivity to the components or a history of allergy to beta-lactam drugs. Those who have had severe allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or shock should avoid its use. Also, patients accompanied by viral diseases such as infectious mononucleosis or lymphoblastic leukemia may have an increased risk of rash when taking this medication, so caution is advised. Patients with a history of liver dysfunction or jaundice must consult before taking this medication, as their symptoms may recur. This drug contains lactose and should not be administered to patients with genetic metabolic disorders, such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption. Patients with impaired liver function may experience worsening liver function due to the drug, so it should be used cautiously, and patients with severe renal impairment may need dosage adjustments due to increased blood drug concentrations. Patients with allergic tendencies or symptoms such as asthma, hives, or rashes should also exercise caution. Patients with gastrointestinal symptoms such as vomiting or diarrhea may have insufficient drug absorption, so they should consult healthcare professionals before taking the medication. If diarrhea, abdominal pain, or bloody stools occur during treatment, the drug should be discontinued immediately and a physician consulted. Liver function abnormalities may also occur rarely, particularly more frequently reported in individuals over 60 years and males. Symptoms such as skin rash, itching, and in severe cases, serious skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis may occur, so the administration should be stopped immediately if such symptoms arise. Rare changes in blood tests, such as leukopenia, thrombocytopenia, and anemia have been reported; thus, regular blood tests are necessary for long-term use. Central nervous system symptoms like agitation, anxiety, drowsiness, and seizures may rarely occur, particularly in patients with impaired renal function or those on high doses. Acute renal failure or nephritis has also been reported, so renal function should be monitored regularly. Oral candidiasis or vaginitis may occur due to antibiotic use, requiring appropriate treatment if symptoms appear. There may be a tendency for bleeding due to vitamin K deficiency, and patients at risk of bleeding should exercise caution. It is important to only administer this drug for the necessary minimum duration after susceptibility testing to prevent the emergence of resistant strains. Patients suspected of hypersensitivity or with a history of allergy to beta-lactam drugs must inform healthcare providers before administration. After administration, patients should be closely monitored due to the potential for severe allergic reactions such as anaphylactic shock. Long-term use may lead to resistant bacterial proliferation and liver function abnormalities; thus, careful monitoring is necessary for usage beyond 14 days. Administration should be avoided during the first trimester of pregnancy and should only occur if the benefits outweigh the risks for pregnant or lactating mothers. While breastfeeding, infants may experience adverse reactions such as diarrhea or skin rash; thus, administration should be stopped if symptoms occur. The safety for premature infants or newborns under 2 months has not been established. Elderly patients may experience adverse reactions more easily due to decreased physiological function, so caution should be exercised in adjusting dosage and intervals. This medication may affect certain clinical test results, so it is recommended to inform healthcare providers of its use during testing. In cases of overdose, gastrointestinal symptoms, renal failure, convulsions, and hypersensitivity shock may occur; immediate discontinuation of the drug and appropriate emergency treatment are required. Store in a dry place below 25 degrees Celsius in a sealed container, and refrigerate after preparation, using within 7 days. Finally, it is very important to consult with healthcare providers before administration to fully inform them of individual health conditions and medical history and to seek professional help immediately in case of adverse reactions.

Serious side effects

Hives, severe swelling (angioedema), tightness in the chest, difficulty breathing, cold sweat, paleness, severe allergic reactions (anaphylaxis, anaphylactic shock, hypotension, laryngeal edema, bronchospasm, shock), high fever with severe rash, blisters, skin peeling, painful mucosa of mouth/eyes, severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, Lyell syndrome, bullous erythema multiforme, acute generalized exanthematous pustulosis

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, loss of appetite, abdominal pain, abdominal distension, constipation, colonic pain, acid reflux, soft stools, dry mouth, candidiasis, antibiotic-associated colitis, bloody stools, itching, erythema multiforme, skin rash, dermatitis, oral edema, eosinophilia, blood disorder (leukopenia, thrombocytopenia, hemolytic anemia, anemia, thrombocytopenic purpura, eosinophilia

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. Also, it is important to keep it in a cool, dry place below 25 degrees Celsius to maintain the drug's effectiveness and safety.

Appearance

A white or pale yellow powder that is dissolved before use as syrup.

Package unit

50mL (5.5057g)/bottle