Clidell Tablet (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer 75 mg of clopidogrel orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start with a loading dose of 300 mg of this drug once daily on the day treatment is initiated, followed by a maintenance dose of 75 mg once daily orally. Aspirin 75 ～ 325 mg should be administered concomitantly with this drug once daily. 3. For patients with atrial fibrillation, administer 75 mg of this drug orally once daily. Aspirin 75 ～ 100 mg should be administered concomitantly with this drug once daily. ○ Patients with renal impairment: Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment: Treatment experience in patients with moderate liver disease and bleeding diathesis is limited. This drug may be administered with or without food.

This drug may be less effective in patients with genetically reduced CYP2C19 enzyme function, requiring modifications to treatment or alternative medications for these patients. Additionally, using this drug with medications that activate the CYP2C19 enzyme may increase the concentration of the active ingredient and heighten the risk of bleeding, hence co-administration is not advisable. Patients with allergies to this drug or its components, active bleeding or severe liver impairment, breastfeeding women, and patients with genetic issues like lactose intolerance should not use this drug. Patients with a high risk of bleeding or blood coagulation abnormalities should use this drug cautiously and seek immediate medical attention if bleeding symptoms occur. Patients scheduled for surgery should discontinue the drug 5 to 7 days before the procedure and resume it only after hemostasis has been achieved. This drug can prolong bleeding time, resulting in various bleeding-related side effects such as gastrointestinal bleeding and ocular bleeding, thus caution is advisable when taken with other medications that carry bleeding risks. Regular monitoring through blood tests for bleeding or hematological adverse reactions is essential. While taking this drug, there may be an increased likelihood of bleeding, so care should be taken to avoid injury, and if bleeding does not stop, immediate medical attention should be sought. During pregnancy, it is believed to have minimal effects on the fetus, but an increased risk of bleeding during delivery may recommend discontinuation of the drug at the time of labor or regional block. For breastfeeding individuals, as this drug may be excreted in breast milk, it is advised to discuss with a medical professional whether to continue breastfeeding or to stop the medication. Elderly patients and those with impaired kidney or liver function may have an increased risk of bleeding, so their condition should be closely monitored before and after intake. In case of overdose, bleeding time may be prolonged, and bleeding complications may arise, thus strict adherence to dosage is necessary, and platelet transfusions or other therapies may be needed in cases of significant bleeding. This drug has not been established for safety and efficacy in children, and its use should be avoided in this population. Caution is required when driving or operating machinery during treatment due to the risk of bleeding, and healthcare professionals should be informed of this medication's use when starting new medications or undergoing surgery.

• Hemorrhage
• gastrointestinal bleeding
• purpura
• contusion
• hematoma
• epistaxis
• hematoma
• hematuria
• intraocular hemorrhage
• intracranial hemorrhage

This drug should be stored in a tightly closed container to prevent exposure to air and moisture, and it is advisable to keep it at a temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the effectiveness of the medication and ensures safe use.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle