Eravix Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

○ Adults 1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, administer clopidogrel 75 mg orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), start treatment on the first day with a loading dose of 300 mg of this medicine once daily, followed by a maintenance dose of 75 mg orally once daily. Aspirin 75 ～ 325 mg should be administered concomitantly with this medicine once daily. 3. For patients with atrial fibrillation, administer 75 mg of this medicine orally once daily. Aspirin 75 ～ 100 mg should be administered concomitantly with this medicine once daily. ○ Patients with renal impairment: Treatment experience in patients with renal impairment is limited. ○ Patients with hepatic impairment: Treatment experience in patients with moderate liver disease with a bleeding diathesis is limited. This medicine may be administered with or without food.

This medication helps prevent platelets from clumping together, ensuring smooth blood flow. The efficacy of this medication may be reduced in individuals with genetically lower function of a specific enzyme (CYP2C19), and in such cases, alternative treatments should be considered. Additionally, using this medication with drugs that activate certain enzymes may increase drug concentration and elevate bleeding risks, therefore, it is advisable not to combine them. Patients with allergies to this medication or its components, patients with severe bleeding, patients with significantly impaired liver function, nursing mothers, and those with lactose intolerance should not take this medication. Patients with bleeding risks or bleeding disorders, or those planned for surgery should use this medication with caution and may need to discontinue it 5 to 7 days before surgery if necessary. This medication may increase bleeding risks when combined with other antiplatelet agents, anticoagulants, non-steroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and similar medications. During the use of this medication, it may take longer for bleeding to stop, so if there is heavy or prolonged bleeding, report immediately to a doctor. Rarely, this medication may cause blood disorders such as thrombocytopenia, agranulocytosis, and aplastic anemia, so consult medical personnel if there are symptoms of infection or unusual symptoms. Gastrointestinal symptoms such as abdominal pain, dyspepsia, diarrhea may occur, as well as allergic reactions like skin rashes or itching. The impact on the fetus during pregnancy is unclear; however, it may be used as needed for treating severe cardiovascular diseases, and discontinuation 5 to 7 days before delivery is recommended due to the risk of bleeding during labor. For nursing mothers, it is uncertain if this medication is secreted in breast milk, so consultation with a doctor is necessary to decide whether to continue nursing or stop the medication. The safety and efficacy in children have not been established yet. Elderly patients may have decreased physiological function and a higher risk of bleeding, thus, dose adjustment and careful monitoring are required. Patients with impaired kidney function should also use this medication cautiously, although dose adjustments are not necessary. In cases of overdose, there may be a risk of bleeding, so adherence to the prescribed dosage is essential, and if heavy bleeding occurs, appropriate treatment like platelet transfusion may be necessary. This medication should be kept out of reach of children and should not be transferred to another container for safety.

• Hemorrhage
• gastrointestinal hemorrhage
• hospitalization necessary for hemorrhage
• purpura
• contusion
• hematoma
• epistaxis
• hematoma
• hematuria
• intraocular hemorrhage

This medication may be sensitive to air or moisture, so it should be stored in a tightly closed container. Additionally, it is best to store the medication at room temperature between 1 degree and 30 degrees Celsius, avoiding extremely hot or cold locations. Proper storage can help maintain the effectiveness of the medication for a longer period.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle