Clopidogrel Tablets (Clopidogrel Hydrochloride)

Adult dose

1. For patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, take 75 mg of clopidogrel orally once daily. 2. For patients with acute coronary syndrome (unstable angina or non-Q wave myocardial infarction), initiate treatment on the first day with a loading dose of 300 mg once daily and then continue with a maintenance dose of 75 mg once daily thereafter. At this time, aspirin 75–325 mg should be taken once daily along with the drug.

This medicine is a drug that inhibits the aggregation of platelets in the blood to prevent thrombus formation. This drug is converted into an active metabolite by a specific enzyme, CYP2C19, in the liver, and its efficacy may be reduced in individuals with genetically impaired function of this enzyme. If the concentration of the active metabolite becomes too high, the risk of bleeding may increase; therefore, it is important to avoid taking it with drugs that activate CYP2C19. Patients with allergies to this drug or its components, those with bleeding, patients with severe liver damage, and nursing mothers should not take this medicine. Patients at high risk of bleeding, patients with poor liver or kidney function, the elderly, and underweight patients should use this drug cautiously, and it is recommended to discontinue the drug 5 to 7 days before any scheduled surgery. Because this drug may increase the risk of bleeding, any bleeding symptoms should be reported immediately to healthcare professionals, and caution is needed when combined with other medications that have a risk of bleeding. During the course of this medication, regular blood tests should be conducted to monitor for bleeding or blood abnormalities. Pregnant women should carefully consider the use of this drug, unless in an emergency, and it is recommended to discontinue medication around the time of delivery due to a risk of bleeding. Nursing mothers should carefully assess whether to breastfeed while taking this drug, as it may be excreted in breast milk. In cases of overdose, bleeding time may be prolonged, and bleeding complications may occur, so it is imperative to adhere to the prescribed dosage. The safety and efficacy of this drug have not been established in children, so its use is not recommended. During the course of this medication, keep a close watch for any unusual symptoms such as bleeding, allergic reactions, gastrointestinal disturbances, skin rashes, headache, dizziness, abdominal pain, dyspepsia, diarrhea, nausea, hypercholesterolemia, arthralgia, back pain, bruising/sprains, epistaxis, depression, upper respiratory tract infections, rhinitis, bronchitis, cough, rash, pruritus, urinary tract infections, decreased motor function, tremors, voice disturbances, abnormal gait, hyperkinesia, ataxia, perceptual abnormalities, constipation, vomiting, and insomnia.

Serious side effects

Urticaria, angioedema, chest tightness, difficulty breathing, cold sweats, paleness, severe rash with high fever, blisters, skin peeling, pain in mouth/eye mucous membranes, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough + fever, jaundice (yellowing of the skin or eyes), severe lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, markedly reduced urine output

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• swelling
• hypertension
• headache
• dizziness
• abdominal pain

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. Additionally, it is best to store the medication at room temperature between 1 and 30 degrees Celsius, away from extreme heat or cold.

Appearance

Pink round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle