Pravixen Tablets (Clopidogrel Hydrogen Sulfate)

Adult dose

1. In patients with ischemic stroke, myocardial infarction, or peripheral arterial disease, Clopidogrel should be taken orally at a dose of 75 mg once daily. 2. In patients with acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), initiate treatment with a loading dose of 300 mg orally once on the day of administration, followed by a maintenance dose of 75 mg orally once daily. 3. In patients with atrial fibrillation, administer 75 mg orally once daily.

This medication helps prevent platelets from clumping together, facilitating better blood flow. This drug is activated into its effective form by a specific enzyme, CYP2C19, in the liver. If a person genetically has a reduced function of this enzyme, the efficacy of this medication may be diminished, prompting a reconsideration of treatment options. Furthermore, taking this medication with drugs that activate CYP2C19 enzyme may increase the risk of bleeding, so it is recommended not to use them together. Patients allergic to this medication or those with active bleeding, severely impaired liver function, and nursing mothers should not take this medication. Moreover, patients who are genetically unable to digest lactose should also refrain from taking this medication. Patients with a high risk of bleeding, issues with blood coagulation, or those who have had recent surgeries should use this medication cautiously. In cases of planned surgery, this medication should be discontinued 5 to 7 days prior, and resumed after hemostasis has been achieved. During the course of this medication, watch for signs of bleeding, and inform your doctor about this medication if you are prescribed new medication or prior to surgery. This medication may increase the risk of bleeding, so extra caution is needed when taken with aspirin or other drugs that affect blood coagulation. Rarely, severe side effects may occur, characterized by a drastic drop in blood cell count; if symptoms of infection or bleeding arise, immediate medical consultation is advised. Pregnant women should only use this medication for severe cardiovascular disease treatment, and should discontinue it during delivery because of the risk of bleeding. Nursing mothers should consider discontinuing breastfeeding or the use of this medication due to the potential for drug transmission to the infant through breast milk. Safety in infants has not been established. Elderly patients should use it cautiously, as impaired kidney or liver function may increase bleeding risk and should follow a doctor's instructions. In case of overdose, bleeding may worsen, and since there is no specific antidote, platelet transfusion may be needed to stop the bleeding. This medication should be stored out of reach of children, and care should be taken not to transfer it to another container as this may compromise its quality.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, peeling skin, pain in oral/ocular mucosa, breathlessness or difficulty breathing, asthma attack, respiratory abnormalities with cough + fever, yellowing of the skin or eyes (jaundice), profound lethargy, sudden severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis,

Mild side effects

• Chest pain
• accidental injury
• influenza-like illness
• pain
• fatigue
• swelling
• hypertension
• headache
• dizziness
• abdominal pain

This medication should be stored in a tightly closed container to prevent air from entering and preferably at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a long time.

Appearance

Pink round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle