Dilatrend SR Capsule 32 mg (Carvedilol)

Adult dose

This medicine should be taken orally with food. Do not increase the dose or discontinue treatment without your doctor’s instructions. This is an extended-release formulation; do not break, crush, or chew it. Swallow the capsule whole. For reference, the daily doses of this medicine (extended-release formulation) equivalent to those of conventional carvedilol formulations are as follows. Daily dose of conventional formulation / Daily dose of extended-release formulation 3.125 mg twice daily / 8 mg once daily 6.25 mg twice daily / 16 mg once daily 12.5 mg twice daily / 32 mg once daily 25 mg twice daily / 64 mg once daily 50 mg twice daily / 128 mg once daily 1. Essential hypertension 1) Adults: Take 16 mg of this medicine once daily for 2 days, then increase to 32mg once daily. The usual dose is 32 mg once daily for 2 weeks; if the effect is insufficient, the dose may be increased to 64mg once daily. The maximum daily dose of this medicine is 64mg. 2) Older adults: A dose of 16 mg of this medicine once daily may provide an adequate therapeutic effect. If the effect is insufficient after 2 weeks of treatment, the dose may be increased; administer cautiously while monitoring the patient’s condition. 2. Chronic stable angina 1) For the first 2 days, administer 32 mg of carvedilol once daily, then administer 64 mg once daily. 2) The usual dose is 64 mg once daily for 2 weeks. If an increase is needed (excluding older adults), administer 128 mg once daily. 3. Congestive heart failure 1) Initial treatment is generally 8 mg of carvedilol once daily for 2 weeks. If the patient tolerates this treatment well, increase to 16 mg once daily for 2 weeks, then increase to 32 mg once daily for 2 weeks, and then increase to 64 mg once daily. 2) After taking each dose for at least 2 weeks, increase the dose gradually up to the maximum dose the patient can tolerate. 3) The minimum effective dose of this medicine is 16 mg once daily. The maximum dose is 64 mg once daily for patients weighing 85 kg or less and 128 mg once daily for patients weighing 85 kg or more. 4. Heart rate control in patients with atrial fibrillation Administer 8mg of this medicine once daily. If the effect is insufficient after 2 weeks, administer 16mg once daily. If the effect remains insufficient after 2 weeks, administer 32mg once daily.

This medication should not be administered to patients with specific diseases or conditions. For instance, patients allergic to this drug or its components, patients with severely weakened heart function, patients with very slow heartbeats or heart conduction issues, patients with pulmonary-related heart diseases, patients with severe metabolic disorders due to diabetes, patients with respiratory diseases like asthma or chronic obstructive pulmonary disease, and women who are pregnant or nursing should not use this medication. Moreover, diabetic patients, patients with a severe allergy history, patients with very low blood pressure or problems with renal or liver function, and elderly patients should use this medication with caution. While taking this medication, symptoms such as dizziness, headache, and fatigue may appear, and heart rates may slow or blood pressure may drop excessively, so regular monitoring of heart function, blood pressure, and heart rate is necessary. Various side effects may appear, including decreased kidney function, difficulty breathing, digestive disturbances, skin rashes, hematological abnormalities, thus, if any abnormal symptoms occur, immediately consult a doctor. Regular examinations of heart, liver, and kidney functions are necessary even with long-term use of this medication, and stopping it abruptly can worsen heart symptoms, so dosage should be gradually reduced according to the doctor's instruction. Since this medication may interact with other drugs, inform your healthcare provider about any other medications being taken, especially if they include antihypertensives, diabetes medications, heart medications, or sedatives. Pregnant or nursing women should not take this medication due to potential risks to the fetus or neonate, and safety in children and adolescents under 18 years has not been established. Elderly patients may experience increased concentrations of this medication due to decreased liver function, thus starting at a lower dose and carefully monitoring their condition is important. Overdosage may result in severe cardiac issues, difficulty breathing, or loss of consciousness; therefore, inform medical personnel immediately and receive appropriate treatment. This medication may discolor when exposed to light, therefore, must be stored in a light-proof container and kept out of reach of children.

Dizziness, headache, fatigue, weakness, hallucinations, delirium, depression, sleep disorders, nightmares, psychosis, severe bradycardia, shock, complete heart block, heart failure, cardiac arrest, significant hypotension, loss of consciousness, decreased pulse rate, cold extremities, edema, worsening heart failure, worsening kidney function, kidney failure, increased respiratory resistance, nausea, diarrhea, abdominal pain, vomiting, constipation, urticaria, itching, lichen planus-like reaction, allergic rash, thrombocytopenia, leukopenia, hypoglycemia, masked hyperthyroidism, bradycardia, hypotension, shortness of breath, hypertension in angina, liver dysfunction, jaundice, limb pain, decreased tears, sensory disturbances, visual disturbances, eye irritation, dry mouth, urination disorders, sexual dysfunction, allergic reactions, facial paralysis, uterine fibroids, subarachnoid hemorrhage, rib fractures, leg fractures, increased triglycerides, increased blood sugar, dizziness, increased blood sugar, hypokalemia, fatigue, dyspepsia, memory disturbances, dizziness, headache, peripheral neuropathy, respiratory distress, epistaxis, cough, wet cough, nasopharyngitis, tinea corporis, soft tissue infection, chronic tonsillitis, diverticulitis, onychomycosis, sepsis, upper respiratory tract infection, diarrhea, abdominal discomfort, upper abdominal pain, constipation, palpitations, chest discomfort, chest pain, fatigue, conjunctival congestion, joint swelling, pruritus, facial flushing, palpitations, heart failure, heart flutter, syncope, decreased blood pressure, increased blood uric acid, increased N-terminal brain natriuretic peptide prohormone, nausea, chest discomfort, leg edema, chest pain, back pain, ankle edema, fever, pain, limb edema, cold, dry cough, cough, gastroesophageal reflux, acute gastritis, gastritis, gastroenteritis, pain in the epigastric region related to food, migraine, blood pressure fluctuations, blood pressure control failure, sting, lipoma, unstable angina, pyelonephritis

This medication is sensitive to light and should be stored in a light-blocking container. Additionally, it is important to store it at room temperature between 1 and 30 degrees Celsius to maintain its efficacy.

Appearance

Hard capsule with a reddish-brown upper part and a white lower part containing white to light yellow instant-release and sustained-release granules

Package unit

30 capsules/bottle, 100 capsules/bottle