Dilatrend SR Capsule 16 mg (Carvedilol)

Adult dose

This medicine should be taken orally with food. Do not increase the dose or discontinue treatment without your doctor’s instructions. This is an extended-release formulation; do not break, crush, or chew it. Swallow the capsule whole. For reference, the daily doses of this medicine (extended-release formulation) equivalent to those of conventional carvedilol formulations are as follows. Daily dose of conventional formulation Daily dose of extended-release formulation 3.125 mg twice daily 8 mg once daily 6.25 mg twice daily 16 mg once daily 12.5 mg twice daily 32 mg once daily 25 mg twice daily 64 mg once daily 50 mg twice daily 128 mg once daily 1. Essential hypertension 1) Adults: Take 16 mg of this medicine once daily for 2 days, then increase to 32mg once daily. The usual dose is 32 mg once daily for 2 weeks; if the effect is insufficient, the dose may be increased to 64mg once daily. The maximum daily dose of this medicine is 64mg. 2) Older adults: A dose of 16 mg of this medicine once daily may provide an adequate therapeutic effect. If the effect is insufficient after 2 weeks of treatment, the dose may be increased; administer cautiously while monitoring the patient’s condition. 2. Chronic stable angina 1) For the first 2 days, administer 32 mg of carvedilol once daily, then administer 64 mg once daily. 2) The usual dose is 64 mg once daily for 2 weeks. If an increase is needed (excluding older adults), administer 128 mg once daily. 3. Congestive heart failure 1) Initial treatment is generally 8 mg of carvedilol once daily for 2 weeks. If the patient tolerates this treatment well, increase to 16 mg once daily for 2 weeks, then increase to 32 mg once daily for 2 weeks, and then increase to 64 mg once daily. 2) After taking each dose for at least 2 weeks, increase the dose gradually up to the maximum dose the patient can tolerate. 3) The minimum effective dose of this medicine is 16 mg once daily. The maximum dose is 64 mg once daily for patients weighing 85 kg or less and 128 mg once daily for patients weighing 85 kg or more. 4. Heart rate control in patients with atrial fibrillation Administer 8mg of this medicine once daily. If the effect is insufficient after 2 weeks, administer 16mg once daily. If the effect remains insufficient after 2 weeks, administer 32mg once daily.

This medication should not be used in certain patients. For example, avoid use in those who are allergic to this medication or its ingredients, those in a state of cardiogenic shock, those with very slow heart rates, patients with cor pulmonale, individuals with metabolic disorders due to diabetes, severe heart failure, or patients with asthma or chronic lung diseases. Additionally, patients with diabetes or certain heart diseases, elderly patients, and those with severely impaired kidney or liver function should use this medication with caution. In such cases, strict observation and management by a physician are necessary. During treatment with this medication, mild symptoms such as dizziness, headache, and fatigue may occur, and rarely central nervous system abnormalities such as confusion or hallucinations may arise. Cardiovascular side effects may include reduced heart rate, lowered blood pressure, and exacerbation of heart failure. Patients with impaired kidney function may experience deterioration of kidney function, and those with respiratory diseases may suffer from dyspnea. Gastrointestinal symptoms may include nausea, diarrhea, abdominal pain, and in rare cases, allergic reactions such as rashes or itching may occur. Long-term use of this medication requires regular heart function tests and checks of blood pressure, pulse, liver, and kidney functions, and sudden discontinuation may exacerbate cardiac symptoms, so dosage should be reduced gradually according to the physician's instructions. This medication may interact with other drugs, so if using other medications that lower blood pressure, diabetes treatments, certain antidepressants or sedatives, or anesthetics, consult a physician or pharmacist. It is safest for women who are pregnant or may become pregnant to avoid this medication, and caution is needed when administering it to children or adolescents as safety and efficacy have not been established. Elderly patients may experience increased drug concentrations due to liver impairment, so they should start from a low dose and be monitored carefully. In the case of overdose, symptoms may include lowered blood pressure, reduced heart rate, decreased heart function, dyspnea, and consciousness disturbances, requiring immediate medical attention and appropriate treatment. This medication may discolor due to light; therefore, store it in a light-blocking container and keep it out of reach of children. Additionally, avoid transferring it to another container as this may adversely affect its quality.

• Dizziness
• headache
• fatigue
• weakness
• hallucination
• confusion
• depression
• sleep disorders
• nightmares
• psychosis

Store this medication in a tightly sealed container that blocks light, as it is sensitive to light. Additionally, to maintain its efficacy, it should be stored at room temperature between 1 degree and 30 degrees.

Appearance

A hard capsule with a light yellow upper part and a white lower part containing white to slightly yellow immediate-release and extended-release granules

Package unit

30 capsules/bottle, 100 capsules/bottle