Dilatrend SR Capsule 8 mg (Carvedilol)

Adult dose

This medicine should be taken orally with food. Do not increase the dose or discontinue treatment without your doctor’s instructions. This is an extended-release formulation; do not break, crush, or chew it. Swallow the capsule whole. For reference, the daily doses of this medicine (extended-release formulation) equivalent to those of conventional carvedilol formulations are as follows. Daily dose of conventional formulation Daily dose of extended-release formulation 3.125 mg twice daily 8 mg once daily 6.25 mg twice daily 16 mg once daily 12.5 mg twice daily 32 mg once daily 25 mg twice daily 64 mg once daily 50 mg twice daily 128 mg once daily 1. Essential hypertension 1) Adults: Take 16 mg of this medicine once daily for 2 days, then increase to 32mg once daily. The usual dose is 32 mg once daily for 2 weeks; if the effect is insufficient, the dose may be increased to 64mg once daily. The maximum daily dose of this medicine is 64mg. 2) Older adults: A dose of 16 mg of this medicine once daily may provide an adequate therapeutic effect. If the effect is insufficient after 2 weeks of treatment, the dose may be increased; administer cautiously while monitoring the patient’s condition. 2. Chronic stable angina 1) For the first 2 days, administer 32 mg of carvedilol once daily, then administer 64 mg once daily. 2) The usual dose is 64 mg once daily for 2 weeks. If an increase is needed (excluding older adults), administer 128 mg once daily. 3. Congestive heart failure 1) Initial treatment is generally 8 mg of carvedilol once daily for 2 weeks. If the patient tolerates this treatment well, increase to 16 mg once daily for 2 weeks, then increase to 32 mg once daily for 2 weeks, and then increase to 64 mg once daily. 2) After taking each dose for at least 2 weeks, increase the dose gradually up to the maximum dose the patient can tolerate. 3) The minimum effective dose of this medicine is 16 mg once daily. The maximum dose is 64 mg once daily for patients weighing 85 kg or less and 128 mg once daily for patients weighing 85 kg or more. 4. Heart rate control in patients with atrial fibrillation Administer 8mg of this medicine once daily. If the effect is insufficient after 2 weeks, administer 16mg once daily. If the effect remains insufficient after 2 weeks, administer 32mg once daily.

This medication should not be used in certain patients. For example, it should not be administered to those with allergies to this medication or its components, those with severely impaired cardiac function, those with bradycardia, those with heart conduction disorders, those with severe right heart failure due to pulmonary hypertension, those with metabolic abnormalities due to diabetes, those with severe heart failure, those with respiratory diseases such as asthma or chronic obstructive pulmonary disease, certain types of hypertension patients, and women who are pregnant or breastfeeding. Furthermore, diabetic patients, those with severe allergic reactions, patients with low blood pressure, those with impaired kidney or liver function, elderly patients, and patients with certain heart conditions need to be especially cautious when using this medication and require strict monitoring and adjustment by a physician. During treatment, central nervous system symptoms such as dizziness, headaches, and fatigue may occur, and heart rate may slow down or blood pressure may drop, necessitating regular checks of heart function and blood pressure. In severe cases, it may be necessary to reduce or stop the medication. Patients with impaired kidney or liver function should be cautious as deterioration of function may occur, and those with respiratory diseases should be monitored for worsening symptoms. This medication can affect blood sugar control, so diabetic patients should frequently check their blood sugar, and patients with hyperthyroidism should be cautious as symptoms may be masked. This medication may interact with other medications, so consultation with a doctor is necessary when taken with other antihypertensives, sedatives, antidepressants, antiarrhythmics, or antidiabetic agents. Women who are pregnant or breastfeeding should not take this medication, and safety in children and adolescents has not been established, so its use is not recommended. In elderly patients, drug concentration may increase due to decreased liver function, so treatment should start at a lower dose and be closely monitored. In cases of overdose, serious symptoms such as low blood pressure, reduced heart rate, decreased cardiac function, and respiratory distress may occur, necessitating immediate notification of medical personnel and appropriate treatment. Patients on long-term treatment should regularly check heart function, blood pressure, liver, and kidney functions, and abrupt cessation of the medication can exacerbate cardiac symptoms, so the dosage should be gradually reduced according to a doctor's instructions. Symptom issues such as dizziness or drowsiness may occur, requiring caution while driving or operating hazardous machinery; dryness of the eyes may cause discomfort for contact lens wearers. This medication may discolor when exposed to light, so keep it in a light-blocking container and store it out of reach of children; it is advisable not to transfer the medication to another container.

Dizziness, headache, fatigue, weakness, hallucinations, confusion, depression, sleep disorders, nightmares, mental illness, severe bradycardia, shock, complete atrioventricular block, heart failure, cardiac arrest, significant decrease in blood pressure, loss of consciousness, decreased pulse rate, cold extremities, edema, worsening of heart failure, worsening renal function, renal failure, increased airway resistance, nausea, diarrhea, abdominal pain, vomiting, constipation, urticaria, itching, lichenoid reaction, allergic rash, changes in serum aminotransferases, thrombocytopenia, leukopenia, hypoglycemia, masking of hyperthyroidism, bradycardia, hypotension, shortness of breath, hypertension in angina, liver dysfunction, jaundice, limb pain, decreased tear production, sensory disturbances, visual disturbances, eye irritation, dry mouth, urination disorders, sexual dysfunction, allergic reactions, facial paralysis, uterine fibroids, subarachnoid hemorrhage, rib fractures, leg fractures, increased triglycerides, increased blood glucose, memory disturbances, indigestion, chest discomfort, chest pain, conjunctival congestion, ligament sprain, joint swelling, pruritus, facial flushing, chest discomfort, leg edema, cold, dry cough, cough, gastroesophageal reflux disease, acute gastritis, gastritis, gastroenteritis, epigastric pain, palpitations, heart flutter, syncope, decreased blood pressure, increased blood uric acid, increased N-terminal brain natriuretic peptide prohormone, nausea, migraine, epistaxis, sinusitis, rhinitis, upper respiratory infection, nasopharyngitis, body tinea, soft tissue infection, chronic tonsillitis, diverticulitis, onychomycosis, sepsis, upper respiratory infection, myocardial infarction, hyperkalemia, pyelonephritis, unstable angina, lipoma, sting, blood pressure fluctuations, blood pressure control failure, blood pressure reduction, myocardial depression, cardiogenic shock, dyspnea, bronchospasm, vomiting, consciousness disorder, generalized seizure, toxic epidermal necrolysis, Stevens-Johnson syndrome, hypoglycemia, bradycardia, respiratory depression, high fever, acute pulmonary edema, worsening heart failure

This medication may be sensitive to light, so it should be stored in a light-blocking container. Additionally, it is recommended to store it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

A hard capsule with a soft pink upper part and a white lower part containing white to pale yellow immediate release and controlled release granules

Package unit

30 capsules/bottle, 100 capsules/bottle