Itraconazole Tablet (Itraconazole Solid Dispersion)

Adult dose

To improve absorption, this drug should preferably be administered immediately after a meal. 1. Short-term treatment This drug continues to exert a therapeutic effect in skin tissue even after discontinuation. Therefore, the final clinical and mycological therapeutic effect should preferably be assessed 2~4 weeks after completing the prescribed course of treatment. 1) Candidal vaginitis: Administer itraconazole 200mg twice daily (morning and evening) for 1 day, or 200mg once daily for 3 days. 2) Tinea versicolor: Administer 200mg once daily for 7 days. 3) Tinea corporis, tinea cruris (jock itch): Administer 100mg once daily for 15 days. 4) Tinea manuum (interdigital), tinea pedis (interdigital): Administer 100mg once daily for 15 days. 5) Tinea manuum (palms), tinea pedis (soles): Administer 100mg once daily for 30 days or 200mg twice daily for 7 days. 6) Oral candidiasis: Administer 100mg once daily for 15 days. 7) Fungal keratitis: Administer 200mg once daily for 21 days. 2. Onychomycosis 1) Pulse therapy Administer 200mg twice daily for 1 week, followed by a 3-week treatment-free interval; this constitutes 1 cycle. Administer up to 2 cycles for infection limited to the fingernails, and up to 3 cycles for infection involving the toenails. Site of onychomycosis Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Toenails (with or without fingernail infection) Treatment Treatment-free Treatment Treatment-free Treatment Fingernails Treatment Treatment-free Treatment Or 2) Continuous therapy Administer 200mg once daily for 3 months. After the end of treatment, the therapeutic effect continues for 3 months in fingernails and 6 months in toenails. 3. Systemic fungal infections In patients with impaired immune function, such as those with neutropenia, AIDS, or organ transplant recipients, the oral bioavailability of this drug may be reduced; if necessary, double the dose. Aspergillosis: 200mg once daily, 2~5 months. For invasive or disseminated disease, increase to 200mg twice daily. Candidiasis: 100~200mg once daily, 3 weeks~7 months. Cryptococcal meningitis: 200mg twice daily, 2 months~1 year. Maintenance therapy: 200mg once daily. Paracoccidioidomycosis: 100mg once daily, 6 months.

This medication should not be used in patients with weakened heart function, especially those with or a history of congestive heart failure, unless life-threatening situations arise. If heart failure symptoms appear while taking this medication, discontinue use immediately. This medication can reduce myocardial contractility, placing additional stress on the heart. Patients with known allergies to this medication or its components should not take it. Furthermore, taking this medication with certain drugs (e.g., some analgesics, anti-arrhythmic agents, anticoagulants, etc.) can lead to severe side effects, so concurrent use is prohibited. Especially, women who are pregnant or may become pregnant, and those who are breastfeeding, should not take this medication, and patients with lactose intolerance should avoid this medication as well. Patients with impaired liver function may have difficulties metabolizing this medication, increasing the risk of side effects; therefore, caution should be taken, and regular liver function tests should be conducted. Patients with reduced kidney function may also require dosage adjustments. This medication may have various side effects, with common symptoms including headache, nausea, abdominal pain, and, rarely, severe hepatotoxicity, allergic reactions, heart abnormalities, hearing loss. If unusual symptoms appear during treatment, consult a healthcare professional immediately. There are many drug interactions with this medication, so inform health professionals about all medications being taken, especially those affecting the heart, liver, and kidneys. Caution is advised as dizziness, visual impairments, and hearing loss may occur while driving or operating machinery. Pregnant women should use very effective contraception while taking this medication, and breastfeeding should be stopped during treatment. Caution should be taken when administering this medication to children and the elderly, and it should only be used when the benefits of treatment outweigh the risks. In case of overdose, there is no specific antidote, so it is essential to receive symptom-based treatment. Finally, this medication should be stored out of reach of children and kept in its original container to maintain quality.

Headache, nausea, abdominal pain, rhinitis, sinusitis, upper respiratory infection, leukopenia, hypersensitivity, taste disorder, perceptual decline, perceptual abnormality, tinnitus, constipation, diarrhea, dyspepsia, bloating, vomiting, liver dysfunction, hyperbilirubinemia, itching, rash, urticaria, polyuria, erectile dysfunction, menstrual disorder, edema, granulocytopenia, thrombocytopenia, anaphylactoid reaction, hyperglycemia, hyperkalemia, hypokalemia, hypomagnesemia, confusion, peripheral neuropathy, dizziness, drowsiness, tremors, heart failure, left ventricular failure, tachycardia, hypertension, hypotension, pulmonary edema, speech disorders, cough, gastrointestinal disorders, liver failure, hepatitis, jaundice, erythematous rash, excessive sweating, myalgia, arthralgia, renal impairment, urinary incontinence, generalized edema, facial edema, chest pain, fever, pain, fatigue, chills, alanine aminotransferase increase, aspartate aminotransferase increase, serum alkaline phosphatase increase, serum lactate dehydrogenase increase, serum urea increase, gamma-glutamyl transferase increase, liver enzyme increase, abnormal urinalysis, leukocytosis, eosinophilia, anemia, vascular edema, serum sickness, angioedema, anaphylaxis, anaphylactic shock, allergic reaction, double vision, visual impairment, hearing loss, ventricular premature contraction, atrial block, palpitations, increased bowel motility, belching, glossitis, stomatitis, abdominal flank pain, pancreatitis, elevated serum total protein, elevated total bilirubin, elevated LAP, decreased appetite, lethargy, brown urine, mucous membrane syndrome, Stevens-Johnson syndrome, toxic epidermal necrolysis, Riel syndrome, erythema multiforme, hair loss, photosensitivity reaction, exfoliative dermatitis, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, elevated BUN, positive urinary protein reaction, positive urinary glucose reaction, decreased libido, drowsiness, shoulder stiffness, insomnia, chest pain, elevated serum triglycerides, flushing, elevated serum uric acid, elevated serum potassium, serum sickness, angioedema, anaphylactic reaction, hypertriglyceridemia, tremors, visual impairment, transient hearing loss, permanent hearing loss, congestive heart failure, dyspnea, pancreatitis, significant hepatotoxicity, toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, erythema multiforme, exfoliative dermatitis, leukocytoclastic vasculitis, hair loss, photosensitivity, increased serum creatine phosphokinase.

Store this medication in a tightly sealed container to prevent air ingress, at temperatures between 1 to 30 degrees Celsius. Proper storage helps maintain the medication's effectiveness.

Appearance

White or light yellow round film-coated tablet

Package unit

28 tablets/bottle, 100 tablets/bottle