Clopam Tablet 250 Milligrams (Famciclovir)

Adult dose

1. Treatment of herpes zoster Adults: Administer famciclovir 250 mg orally 3 times daily for 7 days. It is preferable to start treatment as soon as symptoms appear after infection. 2. Treatment of initial genital herpes infection Adults: Administer 250 mg of this medicine orally 3 times daily for 5 days. It is preferable to start treatment as soon as symptoms appear after infection. 3. Treatment of acute recurrent genital herpes infection Adults: Administer 125 mg of this medicine orally twice daily for 5 days. It is preferable to start treatment during the prodromal period or as soon as symptoms appear after infection. 4. Suppression of recurrent genital herpes Adults: Administer 250 mg of this medicine orally twice daily. Interrupt treatment periodically every 6～12 months to assess whether the natural course of the disease has changed. 5. Patients with renal impairment: Since the creatinine clearance of this medicine is reduced in patients with renal impairment, adjust the dose with caution. The dosage and administration for these patients are as follows. 1) Treatment of herpes zoster and initial genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 250 mg per dose once daily 2) Treatment of acute recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 125 mg per dose twice daily 10～29 125 mg per dose once daily 3) Suppression of recurrent genital herpes infection: Creatinine clearance (mL/min/1.73㎡) Dose 30～59 250 mg per dose twice daily 10～29 125 mg per dose twice daily 4) If only the serum creatinine is known, creatinine clearance can be calculated using the following formula. Men: {body weight (kg) × (140-age)}/ {72 × serum creatinine (mg/dL)} Women: 0.85 × the value calculated for men 5) Patients with renal impairment undergoing hemodialysis For patients undergoing hemodialysis, administration every 48 hours is preferable, taking the dialysis interval into account. A 4-hour hemodialysis session reduces the plasma concentration of this medicine by approximately 75%; therefore, administer this medicine immediately after dialysis. The recommended dose is 250mg for patients with herpes zoster and 125mg for patients with genital herpes. 6. Patients with hepatic impairment: No dose adjustment is necessary in patients with chronic compensated liver disease. There is insufficient treatment experience in patients with overt chronic decompensated liver disease; therefore, a clear recommended dose has not been established.

This medication may not be suitable for certain patients. For instance, patients allergic to this drug or its components, or those with genetic issues such as lactose intolerance, should not take it. Patients with kidney problems should be particularly cautious when using this medication. While taking this drug, symptoms such as headaches, nausea, dizziness, and drowsiness may occur, and especially in the elderly, drowsiness or confusion may occur more frequently. Regular testing may be necessary as changes in blood values can occur. Additionally, skin rashes, itching, and rarely serious skin reactions may occur, so if any unusual symptoms arise, immediate consultation with a healthcare professional is advised. This medication does not completely cure genital herpes, so it is important to avoid sexual contact and maintain safe sexual practices when symptoms are present. If dizziness or drowsiness occurs while taking this medication, it is advised to avoid driving or operating machinery. In patients with severely impaired liver function, effectiveness may be reduced, so caution is required. This medication may interact with other drugs, so be sure to inform healthcare professionals of any other medications you are taking. Women who are pregnant or breastfeeding should carefully consider the benefits and risks before using this medication, and it is recommended that children under 18 do not use it as safety has not been established. Older adults generally do not require dosage adjustment, but if kidney function is poor, dosage adjustment is necessary. In case of overdose, appropriate treatment is required, and blood dialysis can reduce the concentration of the drug in the body. When storing, keep it in a tightly sealed container to prevent air or moisture from entering, and it is best to store it in a cool, dry place below 30 degrees Celsius.

• headache
• nausea
• thrombocytopenia
• leukopenia
• neutropenia
• dizziness
• confusion
• drowsiness
• hallucinations
• palpitations

This medication should be stored in a tightly sealed container to prevent air or moisture from entering. It is also recommended to store it in a cool and dry place below 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

21 tablets (7 tablets/PTP X 3)