Parkinol Tablet 5 mg (Ropinirole Hydrochloride)

Adult dose

1. The appropriate dose should be determined individually, taking efficacy and tolerability into consideration. It is preferable to take the medicine with food 3 times daily to improve gastrointestinal tolerability. Initial treatment: Take 0.25mg 3 times daily. The treatment regimen for the first 4 weeks is as follows: Week 1 2 3 4 Dose per administration (mg) 0.25 0.5 0.75 1.0 Daily dose (mg) 0.75 1.5 2.25 3.0 Maintenance treatment: After the initial treatment, the dose may be increased at 1-week intervals to 3mg daily. Therapeutic effects occur at doses of 3-9mg daily. If symptoms are not adequately controlled or symptom control is not maintained, the ropinirole dose may be increased until a clear therapeutic effect is achieved; however, it should not exceed 24mg daily. 2. When administered as adjunctive therapy to levodopa, the levodopa dose may be gradually reduced by up to approximately 20% of the total dose. 3. When switching from another dopamine agonist to ropinirole, follow the manufacturer's guidelines for discontinuing the previous medicine before starting ropinirole. 4. As with other dopamine agonists, ropinirole should be discontinued gradually by reducing the number of daily doses over the course of 1 week. 5. Patients with mild or moderate renal impairment (creatinine clearance 30-50㎖/min): No dose adjustment is necessary because ropinirole clearance is unchanged. 6. Patients with severe renal impairment (creatinine clearance ＜30㎖/min) or hepatic impairment: Ropinirole is not recommended. 7. Use in older adults: Ropinirole clearance is reduced in patients aged 65 years or older, but the dose for older patients can be adjusted in the usual manner.

Child dose

8. Use in children: Parkinson's disease does not occur in children. Therefore, no studies of ropinirole use in this population have been reported, and it should not be administered to children.

This medication should be used with caution in patients with severe cardiovascular disease. Care should be taken when taking it with other antihypertensive medications or antiarrhythmics as it may cause hypotension or arrhythmia. Patients with significant mental health issues should use this medication only when its therapeutic benefits outweigh the risks. Patients may suddenly experience drowsiness or fall asleep during the daytime while taking this medication, so activities that are hazardous, such as driving or operating machinery, should be avoided. Patients with hypersensitivity, those who are pregnant or breastfeeding, or individuals with certain genetic lactose intolerance should not take this medication. Side effects such as nausea, vomiting, drowsiness, dizziness, hypotension, and swelling may occur, and if symptoms are severe, consulting a doctor is advised. Particularly, Parkinson's disease patients should be cautious as they may experience movement disorders, psychiatric symptoms, or severe drowsiness. If this medication is suddenly discontinued, severe symptoms may arise, so the dosage should be gradually reduced. It should not be taken with other dopamine agonists, and dosage adjustments may be necessary when used with certain antibiotics or hormone therapies. It is safest not to take this medication during pregnancy or breastfeeding, and its use is not recommended for children under 18 years of age. In case of overdose, symptoms such as vomiting, dizziness, hallucinations, and heart problems may occur, and immediate contact with a healthcare facility is required. This medication should be stored out of reach of children, protected from direct sunlight, in a cool and dry place.

• Nausea
• drowsiness
• leg swelling
• abdominal pain
• vomiting
• syncope
• movement disorders
• hallucinations
• confusion
• dizziness

This medication should be stored in a sealed container that blocks light and maintained at a temperature below 25 degrees Celsius. Storing it this way will help maintain the effectiveness of the drug for a longer time.

Appearance

Light blue, convex, pentagonal film-coated tablet

Package unit

30 tablets/bottle