Glimaphin M Tablets 2/500 mg

Adult dose

This medication is administered 1-2 times a day before meals or with meals. The dose can be adjusted based on proper blood glucose monitoring. The initial dose is Glimepiride/Metformin Hydrochloride 2 mg/500 mg, and it can be gradually increased up to 8 mg/2000 mg. Generally, there is little additional effect when Glimepiride is taken in doses greater than 4 mg per day, although some patients may be increased to 6 mg or 8 mg.

This medication may pose a risk of severe lactic acidosis or hypoglycemia; therefore, treatment should be temporarily suspended and a doctor consulted if there is a rapid decline in kidney function or signs of dehydration. This medication should not be used in patients with impaired kidney function; extra caution is required for elderly patients or in situations where kidney function may change. In patients with cardiovascular diseases, the use of this medication may increase mortality; thus, the risks and benefits must be fully considered before treatment. Patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, those who are pregnant, or breastfeeding should not use this medication. Patients at high risk of hypoglycemia, such as those with poor nutritional status, irregular eating patterns, those engaging in vigorous exercise, or those consuming alcohol heavily, should use this medication with caution. This medication may cause gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.), especially at the early stages of treatment, but most symptoms improve over time. Allergic reactions or symptoms of blood abnormalities, liver function abnormalities may occur; if any unusual symptoms arise, medical attention should be sought immediately. Regular checks of blood glucose levels, kidney function, liver function, and blood tests should be conducted to monitor for any abnormalities during the use of this medication. Since this medication may interact with other drugs, it is essential to inform healthcare providers if taking other medications or starting any new ones. Women who are pregnant or planning to become pregnant should avoid using this medication, and it should also be avoided during breastfeeding. Special care is needed when administering to children or elderly patients, particularly as elderly patients may have decreased kidney function requiring dosage adjustments. Overdosing this medication may result in hypoglycemia or lactic acidosis; therefore, strict adherence to the prescribed dosage is crucial, and immediate consultation with healthcare providers is necessary if unusual symptoms occur. Alcohol consumption should be avoided while taking this medication, and treatment should be suspended if there are significant changes in physical condition or during surgery, infection, etc., with consultation from a doctor. Caution should be observed while driving or operating machinery as hypoglycemia or other side effects may pose risks.

Serious side effects

• Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction)
• Severe rash with high fever, blisters, peeling skin, pain of oral/ocular mucosa (severe skin reaction)
• Shortness of breath or difficulty breathing, asthma attacks, breathing difficulties accompanied by cough and fever (respiratory problems)
• Yellowing of the skin or eyes (jaundice), profound drowsiness (liver abnormalities)
• Sudden and severe

Mild side effects

• Gastrointestinal symptoms (diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, dyspepsia, constipation, abdominal pain), can improve with temporary dose reduction
• Metallic taste discomfort, vision impairment, taste disorders, hypothyroidism, magnesium deficiency with diarrhea, encephalopathy, hair loss, weight gain
• Thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia
• Vitamin B12 reduction and megaloblastic anemia,

This medication should be stored in a tightly closed container that allows for good air circulation and kept at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication over time.

Appearance

White oblong film-coated tablets

Package unit

30 tablets/bottle