Podiem Tablet 1/250 Milligrams

Adult dose

This medication is administered 1 to 2 times daily before or with meals. The dosage may be adjusted according to the patient's current treatment regimen, efficacy, and tolerability, with appropriate blood sugar monitoring. Treatment typically starts at a low dosage, and adjustments can be made based on the medications the patient is currently taking and blood sugar levels. In clinical trials, the initial daily dosage was Glymepiride/Metformin Hydrochloride.

This medication can cause severe lactic acidosis or hypoglycemia, so it should be temporarily discontinued if there is a sudden decline in kidney function or symptoms of dehydration. Especially, patients with poor kidney function, severe liver dysfunction, pregnant or breastfeeding women, and those with acute metabolic acidosis should not take this medication. Patients with a high risk of hypoglycemia, such as those with poor nutritional status or irregular meals, reduced kidney function, or severe liver damage, should take this medication cautiously. Gastrointestinal disturbances (diarrhea, nausea, vomiting, etc.) may occur at the beginning of treatment; however, they are mostly temporary and can be reduced by taking the medication with meals. This medication lowers blood sugar, so if symptoms of hypoglycemia (headache, dizziness, trembling, etc.) occur, sugar must be consumed immediately and a doctor should be consulted. Rare complications such as lactic acidosis may occur; if symptoms such as weakness, muscle pain, respiratory distress, or abdominal pain appear, the medication should be stopped immediately and the healthcare provider should be notified. Dosage should be adjusted according to kidney function, and it is important to receive regular kidney function tests. Additionally, there may be interactions with other medications, so all medications currently taken should be reported to healthcare providers, and it is advisable to avoid alcohol. Pregnant or breastfeeding women should not take this medication and should switch to insulin therapy if necessary. Children and the elderly require special attention as the safety and efficacy of this medication have not been sufficiently established.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, hypotension, lactic acidosis, severe allergic reactions, severe hypoglycemia, liver dysfunction (liver damage, jaundice), severe swelling, thrombocytopenic purpura, thrombocytopenia with platelet count below 10,000/μL, severe neurological symptoms (headaches, seizures, confusion, paralysis), cardiac arrest.

Mild side effects

Diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain, nausea, sensation of fullness or pressure in the upper abdomen, unpleasant or metallic taste, visual impairment, erythema, pruritus, rash, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, vitamin B12 deficiency, increased liver enzymes, liver dysfunction, hepatitis, allergic vasculitis, photosensitivity.

This medication should be stored in a tightly sealed container that prevents air from entering, ideally at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication and prevent degradation.

Appearance

White, rectangular film-coated tablet

Package unit

30 tablets/box (10 tablets/blister x 3), 300 tablets/bottle